Postdoctoral Research Fellowship in Biological Informatics for FY 2000

2000财年生物信息学博士后研究奖学金

• 批准号: 0074520
• 负责人: Marjorie Oleksiak
• 金额: $ 10万
• 依托单位: Oleksiak, Marjorie F
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0074520&HistoricalAwards=false
• 关键词: Postdoctoral; Research; Fellowship; Biological; Informatics

This action funds an NSF Postdoctoral Research Fellowship in Biological Informatics for 2000.The research and training plan is in the area of Eukaryotic Genetics and is entitled "Analysis of Microarray Data to Identify Adaptive Promoters". This bioinformatic study will examine sequence variation in proximal promoters of genes involved with metabolic processes, and distinguish "useful" variations (i.e. variations associated with adaptation) from random variations that have no functional significance. Comparisons of microarray analyses of genes expressed in cardiac tissue of different populations of teleost Fundulus, which exhibit different cardiac metabolisms, can identify genes linked to metabolic processes. In Fundulus, genes whose transcription is altered (increased) by transcription factor SP1 will also be identified by using microarray technology, as these genes are preceded by promoter sequences that bind SP1. The subset of genes that are 1. Associated with cardiac metabolism, and 2. Affected by presence and concentration of SP1, will be further examined to determined which variations are adaptive.

这项行动资助了NSF 2000年生物信息学博士后研究奖学金。这项研究和培训计划是在真核遗传学领域，标题为“分析微阵列数据以识别适应性启动子”。这项生物信息学研究将检测与代谢过程有关的基因启动子近端的序列变异，并将“有用的”变异(即与适应相关的变异)与没有功能意义的随机变异区分开来。比较不同种群硬骨鱼心脏组织表达基因的微阵列分析，可以识别与代谢过程相关的基因。在Fundulus中，转录被转录因子SP1改变(增加)的基因也将通过微阵列技术进行鉴定，因为这些基因之前有与SP1结合的启动子序列。1.与心脏代谢相关，2.受SP1的存在和浓度影响的基因子集将被进一步检查，以确定哪些变异是适应性的。