Relay Catalysis with Supported Early and Late Metal Catalysts

该项目的目标是开发将通常不相容的早过渡金属催化剂和晚过渡金属催化剂相结合的方法，以执行多步催化转化。特别是，早期过渡金属Lewis酸催化剂将与晚期过渡金属氧化还原催化剂结合，实现一锅转化。由于这种催化剂通常不能在溶液中共存，它们将通过将它们固定在固体有机载体上来分离。为了实现立体选择性催化，除了分子印迹方法外，还将研究可聚合的手性辅助配体。有了这个奖，有机和高分子化学计划的有机合成计划支持了北卡罗来纳大学教堂山分校的米歇尔·R·加涅教授的研究。加涅教授的研究涉及使用金属作为催化剂来实现有用的有机反应。由于几种金属催化剂的使用方式各不相同，加涅教授正在努力开发一种策略，使一个反应容器中可以同时使用多种催化剂。这将显著提高在实验室或工业环境中生产合成产品的效率。

This project has as its aim the development of methodology that couples normally incompatible early and late transition metal catalysts, to perform multistep catalytic transformations. In particular, early transition metal Lewis acid catalysts will be coupled with late transition metal redox catalysts to enable one-pot transformations. Since such catalysts cannot normally coexist in solution, they will separated by immobilizing them onto solid organic supports. To achieve stereoselective catalysis, polymerizable chiral ancillary ligands will be examined in addition to a molecular imprinting approach.With this Award, the Organic and Macromolecular Chemistry Program's Organic Synthesis Program supports the research of Professor Michel R. Gagne of the University of North Carolina, Chapel Hill. Professor Gagne's research involves the use of metals as catalysts to bring about useful organic reactions. Since several kinds of metal catalysts are used in a variety of ways, Professor Gagne is working to develop strategies whereby more than one catalyst can be employed concurrently in a single reaction vessel. This will significantly increase the efficiency with which synthetic products can be produced in a laboratory or industrial setting.