International Fellow Awards: International Research Fellow Award: Engineered Polymeric Biomaterials for Modulating Cell Adhesion and Remodeling After Balloon Angioplasty

国际研究员奖：国际研究员奖：用于调节球囊血管成形术后细胞粘附和重塑的工程聚合生物材料

• 批准号: 0076211
• 负责人: Dror Seliktar
• 金额: $ 8.62万
• 依托单位: Seliktar, Dror
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0076211&HistoricalAwards=false
• 关键词: International; Fellow; Awards; Research; Award

0076211SeliktarThe International Research Fellow Awards Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad.This award will provide Dr. Dror Seliktar with support for 24 months to work with Professor Jeffrey A. Hubbell at the Swiss Federal Institute of Technology (ETH) and the University of Zurich in Switzerland.This project will focus on the development and in vitro testing of specialized synthetic hydrogels that are used to regulate the injury response after balloon angioplasty. Hydrogel biomaterials will be developed with functional components (polypeptides) designed to promote both endothelial cell adhesion and endothelial cell-mediated enzyme (MMP-2) activation, while exhibiting susceptibility to the activated MMP-2 enzyme. Testing the functional characteristics will be done in vitro using a set of carefully designed cell culture experiments.The host, Professor Hubbell has a large, active group at one of the strongest research centers in the world in this area of research.

0076211 Seliktar国际研究员奖励计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。 该计划的奖项提供了联合研究的机会，以及使用国外独特或互补的设施，专业知识和实验条件。该奖项将为Dror Seliktar博士提供24个月的支持，与Jeffrey A.瑞士联邦理工学院（ETH）和瑞士苏黎世大学的Hubbell说。该项目将集中于专门的合成水凝胶的开发和体外测试，用于调节球囊血管成形术后的损伤反应。水凝胶生物材料将开发具有功能性组分（多肽），旨在促进内皮细胞粘附和内皮细胞介导的酶（MMP-2）活化，同时对活化的MMP-2酶表现出敏感性。 测试功能特性将在体外使用一套精心设计的细胞培养实验进行。主持人Hubbell教授在世界上最强大的研究中心之一拥有一个庞大而活跃的研究小组。