International Fellow Awards: International Research Fellow Award: Engineered Polymeric Biomaterials for Modulating Cell Adhesion and Remodeling After Balloon Angioplasty

Seliktar国际研究员奖励计划使美国科学家和工程师能够在国外进行3至24个月的研究。该计划的奖项提供了联合研究的机会，以及利用国外独特或互补的设施、专业知识和实验条件的机会。该奖项将为Dror Seliktar博士提供24个月的支持，以便与瑞士联邦理工学院(ETH)和瑞士苏黎世大学的Jeffrey A.Hubbell教授合作。该项目将专注于专门的合成水凝胶的开发和体外测试，这些水凝胶用于调节球囊血管成形术后的损伤反应。水凝胶生物材料将开发具有功能成分(多肽)的生物材料，旨在促进内皮细胞黏附和内皮细胞介导酶(MMP2)的激活，同时表现出对激活的MMP2酶的敏感性。将使用一系列精心设计的细胞培养实验在体外测试功能特性。东道主哈贝尔教授在这一领域世界上最强大的研究中心之一拥有一个庞大的活跃小组。

0076211SeliktarThe International Research Fellow Awards Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad.This award will provide Dr. Dror Seliktar with support for 24 months to work with Professor Jeffrey A. Hubbell at the Swiss Federal Institute of Technology (ETH) and the University of Zurich in Switzerland.This project will focus on the development and in vitro testing of specialized synthetic hydrogels that are used to regulate the injury response after balloon angioplasty. Hydrogel biomaterials will be developed with functional components (polypeptides) designed to promote both endothelial cell adhesion and endothelial cell-mediated enzyme (MMP-2) activation, while exhibiting susceptibility to the activated MMP-2 enzyme. Testing the functional characteristics will be done in vitro using a set of carefully designed cell culture experiments.The host, Professor Hubbell has a large, active group at one of the strongest research centers in the world in this area of research.