Development of a High Fields Solid State NMR Console for Biomaterials Research and Student Training

开发用于生物材料研究和学生培训的高场固态核磁共振控制台

• 批准号: 0076276
• 负责人: Gary Drobny
• 金额: $ 9.49万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0076276&HistoricalAwards=false
• 关键词: Development; Fields; Solid; State; NMR

0076276DrobnyThis award to the University of Washington is for the development of high fields solid state nuclear magnetic resonance (SSNMR) console for biomaterials research and student training. A common challenge in the molecular bioengineering field is the characterization of biomolecules at material surfaces. SSNMR has the potential to fill a particularly crucial gap in our knowledge by defining the secondary structure of proteins adsorbed onto material surfaces, determining protein dynamics at surfaces, and by providing high-resolution structural maps of protein-surface interactions. This award will allow the University of Washington to upgrade a 500 megahertz, 15 years old solid state NMR console. The new console will dramatically expand the biomaterials program at the university by enabling scientsists to perform NMR studies of biomaterials at high magnetic fields and at reduced temperatures. The NMR console will also be equipped with a refrigeration system for cooling samples to temperatures as low as 200K. The console will also be capable of performing SSNNM experiments at Larmor frequencies as high as 1,000 MHz. This award to the University of Washington is for the development of high fields solid state nuclear magnetic resonance (SSNMR) console for biomaterials research and student training. A common challenge in the molecular bioengineering field is the characterization of biomolecules at material surfaces. This award will allow the University of Washington to upgrade a 500 megahertz, 15 years old solid state NMR console. The new console will dramatically expand the biomaterials program at the university by enabling scientists to perform NMR studies of biomaterials at high magnetic fields and at reduced temperatures. The NMR console will also be equipped with a refrigeration system for cooling samples to temperatures as low as 200K on the absolute temperature scale. The instrument will be used in student traing.

0076276 Drobny授予华盛顿大学的这一奖项是为了开发用于生物材料研究和学生培训的高场固态核磁共振（SSNMR）控制台。分子生物工程领域的一个共同挑战是材料表面生物分子的表征。SSNMR有可能通过定义吸附在材料表面上的蛋白质的二级结构，确定表面的蛋白质动力学，并通过提供蛋白质-表面相互作用的高分辨率结构图来填补我们知识中的一个特别重要的空白。该奖项将使华盛顿大学能够升级一个500兆赫、已有15年历史的固态核磁共振控制台。新的控制台将大大扩展该大学的生物材料项目，使科学家能够在高磁场和低温下对生物材料进行NMR研究。NMR控制台还将配备一个制冷系统，用于将样品冷却到低至200 K的温度。该控制台还将能够在高达1,000 MHz的拉莫尔频率下进行SSNNM实验。授予华盛顿大学的这一奖项是为了开发用于生物材料研究和学生培训的高场固态核磁共振（SSNMR）控制台。分子生物工程领域的一个共同挑战是材料表面生物分子的表征。该奖项将使华盛顿大学能够升级一个500兆赫、已有15年历史的固态核磁共振控制台。新的控制台将大大扩展该大学的生物材料项目，使科学家能够在高磁场和低温下对生物材料进行NMR研究。NMR控制台还将配备一个制冷系统，用于将样品冷却到绝对温标上低至200 K的温度。 该仪器将用于学生培训。