Regenerative Neurogenesis in Echinoderms

棘皮动物的再生神经发生

• 批准号: 0076347
• 负责人: Jose Garcia-Arraras
• 金额: $ 4.54万
• 依托单位: University of Puerto Rico-Rio Piedras
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0076347&HistoricalAwards=false
• 关键词: Regenerative; Neurogenesis; Echinoderms

0076347Garcia ArrarasNeurogenesis, or the process by which new nerve cells are formed, is anunusual phenomenon in adult vertebrates. The proposed work focuses on theregeneration of the nervous system, particularly on the neurogenesis thatoccurs after tissue loss or damage. Holothurians or sea cucumbers will beused to study the formation of new nerve cells, or neurons, in adultorganisms. First, the work aims to explore the regeneration capacities ofthe main nervous system and the associated events of cell division andconversion of the dividing cells into neurons. Second, it studies theregeneration of the enteric nervous system, or the component of thenervous system associated with the digestive tract. Finally, it studiesgenes coding for proteins known to be important in regenerative andembryological processes. Cellular, histological and molecular techniqueswill be used to achieve these aims. Neuron loss is associated with mental and motor diseases, learningimpairment, memory loss and many other nervous system-related problems.Echinoderms are well known for their amazing regeneration capacities.Studying regenerative neurogenesis in these animals, which are closelyrelated to vertebrates, will provide basic information on theunderstanding of how neurons are formed and regenerated.

0076347 Garcia Arraras神经发生，或新神经细胞形成的过程，是成年脊椎动物中的一种罕见现象。这项工作的重点是神经系统的再生，特别是在组织损失或损伤后发生的神经发生。海参或海参将被用于研究成年生物体中新神经细胞或神经元的形成。首先，这项工作旨在探索主神经系统的再生能力以及细胞分裂和分裂细胞转化为神经元的相关事件。其次，它研究肠神经系统的再生，或与消化道相关的神经系统的组成部分。最后，它研究了已知在再生和胚胎学过程中重要的蛋白质编码基因。细胞学、组织学和分子生物学技术将被用于实现这些目标。神经元的缺失与精神和运动疾病、学习障碍、记忆丧失以及许多其他神经系统相关的问题有关，棘皮动物以其惊人的再生能力而闻名，研究棘皮动物的再生神经发生将为理解神经元的形成和再生提供基础信息。