Phenotyping doublecortin+ cells to unravel human adult neurogenesis

双皮质素细胞表型分析揭示人类成人神经发生

• 批准号: DP230101981
• 负责人: Dr Natalie Matosin
• 金额: $ 45.17万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-12-31 至 2026-12-30
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP230101981
• 关键词: Phenotyping; doublecortin+; cells; unravel; human

This project investigates one of the brain’s most remarkable phenomena: adult neurogenesis, the birth of new brain cells in a specialised brain area (the hippocampus) occurring well into adulthood. This process contributes to many species’ capacity to learn, remember and regenerate. However whether this process occurs in humans is heavily debated. Using new neuroscience tools, this project will produce new insights into human adult neurogenesis by deeply examining hippocampal cells that express the newborn cell marker, doublecortin. This will enable clarification of the existence and extent of adult neurogenesis in humans, and provide the foundation to leverage this process for improving learning, memory and brain regeneration in people.

该项目研究大脑最显着的现象之一：成年神经发生，在一个专门的大脑区域（海马体）的新脑细胞的诞生发生在成年期。这个过程有助于许多物种的学习，记忆和再生能力。然而，这一过程是否发生在人类身上仍有很大争议。利用新的神经科学工具，该项目将通过深入研究表达新生细胞标记物doublecortin的海马细胞，对人类成年神经发生产生新的见解。这将有助于澄清人类成年神经发生的存在和程度，并为利用这一过程改善人类的学习，记忆和大脑再生提供基础。