Applications of Bismuth Compounds in Organic Synthesis

铋化合物在有机合成中的应用

• 批准号: 0078881
• 负责人: Ram Mohan
• 金额: $ 12.4万
• 依托单位: Illinois Wesleyan University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078881&HistoricalAwards=false
• 关键词: Applications; Bismuth; Compounds; Organic; Synthesis

In this project, a variety of functional group transformations such as cleavage of epoxides, rearrangement of epoxides to carbonyl compounds and cyclization of epoxy-polyenes will be attempted using various bismuth compounds. These reactions will exploit the Lewis acidity of several bismuth(III) compounds as well as the oxidizing power of bismuth(V) reagents. In light of increased awareness of environmental issues and the low toxicity of bismuth compounds, the successful completion of this project will make a significant contribution to this end.With this Award, the Organic and Macromolecular Chemistry Program's Organic Synthesis Program supports the research of Professor Ram S. Mohan of Illinois Wesleyan University. Professor Mohan and his undergraduate students of chemistry will undertake a systematic investigation of the applications of bismuth compounds in synthetic organic chemistry. Bismuth compounds are attractive candidates for use as reagents in organic synthesis because of their low toxicity and ready availability at low cost.

在这个项目中，将尝试使用各种铋化合物进行各种官能团的转化，如环氧化物的裂解、环氧化物重排为羰基化合物和环氧多烯的环化。这些反应将利用几种铋(III)化合物的Lewis酸性以及铋(V)试剂的氧化能力。鉴于人们对环境问题认识的提高和铋化合物的低毒，该项目的成功完成将为实现这一目标做出重大贡献。有了这个奖项，有机和高分子化学项目的有机合成项目支持伊利诺伊州卫斯理大学的Ram S.Mohan教授的研究。莫汉教授和他的化学本科生将对铋化合物在合成有机化学中的应用进行系统的研究。铋化合物具有低毒、易得、成本低等优点，是有机合成中极具吸引力的试剂。