Acquisition of Equipment for Multidisciplinary NMR Upgrade for Polymer Science and Chemistry/Biochemistry

采购高分子科学和化学/生物化学多学科核磁共振升级设备

• 批准号: 0079450
• 负责人: Lon Mathias
• 金额: $ 63.8万
• 依托单位: University of Southern Mississippi
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0079450&HistoricalAwards=false
• 关键词: Acquisition; Equipment; Multidisciplinary; NMR; Upgrade

NMR is the single most important analysis tool in the Departments of Polymer Science and Chemistry-Biochemistry at the University of Southern Mississippi (USM). This award will allow upgrade of five existing spectrometers to current technology (new consoles, electronics and probes for 3 solution and 2 solid state instruments) plus allow purchase of a much-needed 500 MHz instrument for determining primary and secondary structures of natural polymers such as peptides and poly(amino acids) that cannot be done now at USM. These new capabilities will greatly enhance hands-on educational efforts for on-campus and summer students (REU programs in both departments), and those that participate in summer activities and professional development workshops (for industry and for college and K-12 teachers). Research projects address a broad range of fundamental questions on polymer diffusion and relaxation, morphology, enzyme-substrate interaction and structure-property behavior. Most important is the capability these upgrades will provide for expanding previous efforts at USM in developing new methods for understanding solid state behavior of synthetic and natural materials using a wide-range of isotopic labels including carbon, nitrogen and deuterium.%%%%Public AbstractUnderstanding how atoms and molecules are joined together, and how they pack and move in solutions and in the solid state, helps solve problems in medicine, and in the aerospace and automotive areas. One technique that is unique in providing this fundamental knowledge uses NMR or nuclear magnetic resonance spectroscopy. This method, which is similar to Magnetic Resonance Imaging (MRI) used in looking inside the human body, actually looks at the atoms in plastics and enzymes to provide information on what those atoms are doing undergo strain or when they interact with other molecules like drugs. This award for upgrading and extending the NMR capabilities at the University of Southern Mississippi makes available state-of-the-art instruments for doing this type of analysis. Basic problems being addressed with this equipment include, for example, ways of improving the properties of polymers like nylon so it can be used in the automotive and aerospace industries to reduce weight and increase fuel efficiency. In the biomedical area, studying the natural polymers that make up the human body and keep us healthy will help us understand the problems such aging and cancer. This information also gives clues on how to develop new drugs and new materials that can repair or replace worn out and diseased organs. Most important is how the award will help educate students in Mississippi in basic science that will help them in careers in education, technology and medicine that will benefit all of America.

NMR是南密西西比大学（USM）高分子科学系和化学-生物化学系最重要的分析工具。 该合同将允许将现有的五台光谱仪升级到当前的技术（新的控制台，电子设备和探针用于3种解决方案和2种固态仪器），并允许购买急需的500 MHz仪器，用于确定天然聚合物的一级和二级结构，如肽和聚（氨基酸），这在USM目前无法完成。 这些新的功能将大大提高实践教育工作的校园和暑期学生（在两个部门的REU计划），以及那些参加夏季活动和专业发展研讨会（行业和大学和K-12教师）。 研究项目涉及聚合物扩散和松弛，形态，酶-底物相互作用和结构-性质行为等广泛的基本问题。 最重要的是，这些升级将扩大USM以前的努力，开发新方法，使用广泛的同位素标记（包括碳，氮和氘）来理解合成和天然材料的固态行为。了解原子和分子是如何结合在一起的，以及它们在溶液和固态中是如何包装和移动的，有助于解决医学、航空航天和汽车领域的问题。 在提供这种基本知识方面独特的一种技术是使用NMR或核磁共振光谱法。 这种方法类似于用于观察人体内部的磁共振成像（MRI），实际上是观察塑料和酶中的原子，以提供有关这些原子正在经历应变或何时与药物等其他分子相互作用的信息。 该奖项旨在升级和扩展南密西西比大学的NMR能力，为进行此类分析提供最先进的仪器。 该设备解决的基本问题包括，例如，改善尼龙等聚合物性能的方法，使其可用于汽车和航空航天工业，以减轻重量并提高燃油效率。 在生物医学领域，研究组成人体并保持我们健康的天然聚合物将有助于我们了解衰老和癌症等问题。 这些信息也为如何开发新药物和新材料提供了线索，这些药物和新材料可以修复或替换磨损和患病的器官。 最重要的是，该奖项将如何帮助教育学生在密西西比在基础科学，这将有助于他们在职业生涯中的教育，技术和医学，将有利于所有美国。