New Functional Acrylates

这项研究涉及阿尔法的化学- 丙烯酸羟甲基酯（HMA）的合成、聚合和 特征化 丰富化学的拓展与探索 各种烷基酯（RHMA）将使可聚合的 具有卤化物、酯、醚、甲硅烷基醚、氨基甲酸酯、 和胺基。 其中许多还将具有硅氧烷， 烃和碳氟化合物残留物。 反应性低聚物， 内部和末端基团将使用新的- 发现了RHMA醇基的醚形成反应。 也 可用的是具有超亲核催化剂基团的单体， 和能够形成可聚合胶束，囊泡， 单层和液晶态。 环化聚合 醚二聚体生成具有侧链的含吡喃聚合物 具有潜在抗癌和抗病毒活性的羧酸酯基团 活动 反应性卤化物和异氰酸酯的形成 RHMA扩展了单体的功能能力， 聚合物到许多其他衍生物。 阴离子和基团转移 醚和甲硅烷基醚的聚合将允许全同立构和 控制MW聚合物的形成。 研究还将涉及 分子内六元环氢键对聚合物影响 溶解度和物理性质，空间位阻 通过α-甲基取代基的聚合，以及叔丁基 从而形成高分子量的环状聚合物。

This research deals with the chemistry of alpha- hydroxymethylacrylate (HMA) ester synthesis, polymerization, and characterization. Extension and exploration of the rich chemistry of various alkyl esters (RHMAs) will make available polymerizable derivatives possessing halide, ester, ether, silyl ether, urethane, and amine groups. Many of these will also possess siloxane, hydrocarbon, and fluorocarbon residues. Reactive oligomers with internal and terminal groups will be synthesized using a newly- discovered ether-forming reaction of the RHMA alcohol groups. Also available will be monomers with supernucleophilic catalyst groups, and monomers capable of forming polymerizable micelles, vesicles, monolayers, and liquid crystalline states. Cyclopolymerization of the ether dimers generates pyran-containing polymers with pendent carboxylate groups with potential anticancer and antiviral activity. Formation of reactive halides and isocyanates of the RHMA's extends the functional capability of the monomers and polymers to many other derivatives. Anionic and group transfer polymerizations of ethers and silyl ethers will allow isotactic and controlled MW polymer formation. Studies will also deal with intramolecular 6-membered ring hydrogen bond effects on polymer solubility and physical properties, steric inhibition of polymerization by a-methyl substituents, and use of the t-butyl effect to form high molecular weight cyclopolymers.