A Workshop: An Exploration of the Challenges to Assemble the Tree of Life (Yale University Peabody Museum of Natural History/July 28-30, 2000)

研讨会：探索组装生命之树的挑战（耶鲁大学皮博迪自然历史博物馆/2000 年 7 月 28-30 日）

• 批准号: 0089975
• 负责人: Joel Cracraft
• 金额: $ 3.91万
• 依托单位: American Museum Natural History
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2003-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0089975&HistoricalAwards=false
• 关键词: Workshop; Exploration; Challenges; Assemble; Tree

0089975Cracraft and DonoghuePhylogenetic groupings of organisms are the basis for predictive classifications and biological information systems. Organizing biological knowledge and their parallel hierarchies according to phylogenetic relationships has become increasingly important for many segments of science and society (i.e., genetic databases such as GenBank). Yet, our understanding of the tree of life is still very incomplete at all taxonomic levels because phylogenetic hypotheses are typically characterized by inadequate taxon samples, and the data themselves are often variable across the included taxa with respect to kind, quantity, and quality. In addition, methods of analysis vary in their appropriateness and applicability, thus making comparison of phylogenetic trees difficult. These impediments need to be addressed if we are to have a tree of life for the major groups of organisms within a reasonable time frame. Equally important will be to ensure that phylogenetic knowledge is accessible and useful to researchers, institutions, and the government agencies who need it.This proposal seeks to bring together approximately 25-30 leading systematic biologists and nonsystematists interested in phylogenetic research and informatics (phyloinformatics). The workshop will attempt to identify the research needed to assemble the tree of life and make that information available to the global user community within a reasonable time frame. The workshop will formulate recommendations designed to promote institutional changes within the systematic research community to accelerate phylogenetic understanding, identify research efforts that will result in large-scale increases in phylogenetically informative data and improve data analysis, and specify research, technological advances, and infrastructural needs to store, retrieve, and manipulate large amounts of phylogenetic information and make it widely avail

生物体的系统发育分类是预测分类和生物信息系统的基础。根据系统发育关系组织生物学知识及其平行等级对于科学和社会的许多部门(即遗传数据库，如GenBank)来说已变得越来越重要。然而，我们对生命树的理解在所有的分类水平上仍然是非常不完整的，因为系统发育假说通常以不充分的分类样本为特征，而且数据本身在所包括的分类群中往往在种类、数量和质量方面是不同的。此外，分析方法的适当性和适用性各不相同，因此很难进行系统发育树的比较。如果我们要在合理的时间框架内为主要生物体群体建立一棵生命之树，就需要解决这些障碍。同样重要的是确保系统发育知识对研究人员、机构和需要它的政府机构是可获得和有用的。这项建议寻求将大约25-30名对系统发生研究和信息学(系统信息学)感兴趣的领先的系统生物学家和非系统学家聚集在一起。讲习班将试图确定组装生命之树所需的研究，并在合理的时间范围内向全球用户社区提供这些信息。研讨会将提出建议，旨在促进系统研究界的制度变革，以加速系统发育理解，确定将导致系统发育信息数据大规模增加和改进数据分析的研究努力，并具体说明存储、检索和操纵大量系统发育信息并使其广泛使用的研究、技术进步和基础设施需求。