Interactions Between Neurohormonal Systems: Studies at the Cellular Level

神经激素系统之间的相互作用：细胞水平的研究

• 批准号: 0090730
• 负责人: Edward Kravitz
• 金额: $ 28.26万
• 依托单位: Harvard University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2005-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0090730&HistoricalAwards=false
• 关键词: Interactions; Between; Neurohormonal; Systems; Studies

A common behavior among animals is aggression, which can occur during competition for food, mates, or other limited resources. As a consequence of winning or losing fights with other individuals in the same social group, subsequent behavioral patterns change, as winners can dominate losers. A biochemical compound, the amine serotonin, is known to be important in aggression, but other hormonal substances also have been implicated including peptides and steroids, which may interact with amines. The lobster is a social crustacean that shows complex stereotyped behavior, and offers the opportunity to examine the hormonal modulation of behavior at the level of single identifiable cells in the brain. Specific sets of cells containing amines have been mapped, and a group of neurons containing stress-related peptides has been identified that interact with the amine neuron sets. This project examines the cellular networks of the lobster neurons containing and responsive to serotonin and certain peptides and steroids. Electrophysiological recordings and morphological analyses will reveal how the systems are activated, and detail the synaptic interactions and circuitry involved. Results will be important for behavioral neuroscience as well as neuroendocrinology, in clarifying cellular mechanisms underlying the hormonal regulation of aggression, which is an important behavior in humans as well as animals. This project also will have an impact through its excellent integration of education and training with research, including worldwide collaborations and outreach to under-represented groups.

动物之间的一种常见行为是侵略，这可能发生在食物，配偶或其他有限资源的竞争中。 在与同一社会群体中的其他个体的争斗中获胜或失败的结果是，随后的行为模式发生变化，因为胜利者可以支配失败者。 一种生化化合物，胺-血清素，已知在攻击中很重要，但其他激素物质也有牵连，包括肽和类固醇，它们可能与胺相互作用。 龙虾是一种社会甲壳类动物，表现出复杂的刻板行为，并提供了在大脑中单个可识别细胞水平上检查行为的激素调节的机会。 含有胺的细胞的特定集合已经被绘制出来，并且已经确定了一组含有与胺神经元集合相互作用的应激相关肽的神经元。 这个项目研究了龙虾神经元的细胞网络，这些神经元含有血清素和某些肽和类固醇，并对血清素和某些肽和类固醇产生反应。 电生理记录和形态学分析将揭示系统是如何被激活的，并详细说明所涉及的突触相互作用和电路。 这些结果对于行为神经科学和神经内分泌学非常重要，有助于阐明攻击性激素调节的细胞机制，攻击性是人类和动物的一种重要行为。 该项目还将通过其教育和培训与研究的完美结合产生影响，包括世界范围的合作和对代表性不足的群体的宣传。