GOALI: Gas-Phase Reactions of Neutral Organic Molecules Desorbed by Laser-Induced Acoustic Waves

目标：激光诱导声波解吸中性有机分子的气相反应

• 批准号: 0092119
• 负责人: Hilkka Kenttamaa
• 金额: $ 31.05万
• 依托单位: Purdue University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-15 至 2004-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0092119&HistoricalAwards=false
• 关键词: GOALI; Gas; Phase; Reactions; Neutral

With this GOALI award, the Organic and Macromolecular Chemistry Program in the Chemistry Division and the MPS Office of Multidisciplinary Activities supports the work of Dr. Hilkka I. Kenttamaa of the Department of Chemistry at Purdue University in West Lafayette, Indiana and Dr. David Aaserud of the Lubrizol Corporation. A high-risk/high-gain research project involving Purdue University and Lubrizol Corporation is proposed for the study of optoacoustic desorption as a means to evaporate neutral molecules into mass spectrometers. The goal is to determine whether the combination of laser-induced acoustic desorption (LIAD) with gas-phase ion-molecule reactions involving mass-selected reagent ions provides benefits in mass spectrometric characterization of thermally labile and/or nonvolatile molecules. Preliminary experiments confirm the feasibility of the concept, demonstrate high predictability and reproducibility, and suggest some intriguing possibilities. For example, the ability to bring neutral (not ionic) nonvolatile and/or thermally labile molecules into the gas phase would allow a variety of fundamental thermochemical, structural and reactivity studies that currently cannot be carried out. Further, this simple approach may provide an attractive complement to MALDI in qualitative analysis. A matrix should not be necessary, which may lead to better predictability. The physical separation of the evaporation and ionization events should permit the use of many different types of ionization reactions, thus providing control over reaction products and thermochemistry, and access to a variety of information for a given analyte. Finally, this approach should allow mass spectrometric characterization of some compounds that are currently not amenable to such analysis.Dr. David Aaserud, the Co-PI on the award, will commit 5-10% of his time and resources to the proposed work where he will jointly advise participating graduate students and provide polymer characterization expertise to the project. Interaction will include monthly progress reviews and the supervision of one or two doctoral students during work at Lubrizol. The students will be exposed to Lubrizol's analytical capabilities and to an industrial environment. Lubrizol will provide relevant samples and access to any appropriate additional analytical information, including GPC, LC, and NMR data. In the technology transfer stage, the laboratories at Lubrizol will be accessible for applications of the new technologies to industrial samples. The Lubrizol Corporation has provided financial support to graduate students and research projects in Professor Kenttamaa's laboratory over several years. Lubrizol is committed to continue this funding as part or their cost sharing. Lubrizol views the collaborative effort as a continuation of its interaction with Professor Kenttamaa's group with a significant increase in the commitment of resources.The proposed research is at the frontiers of mass spectrometry in studies of the selective transfer of molecules from the solid phase to the gas phase. Lubrizol's interest in derivatized polyalphaolefins arises from the fact that these substances are important components of many lubricant additives. The development of new and better methods to characterize hydrocarbon polymers and their functionalized derivatives will allow a better understanding of these materials and help Lubrizol to better predict product performance. With the support of the Organic and Macromolecular Chemistry Program and the MPS Office of Multidisciplinary Activities, the PI is able to perform potentially ground-breaking research as well as work with an industrial partner to explore real-world applications of the research. Professor Kenttamaa has a large group of undergraduate and graduate students who are female or from underrepresented groups. For them the research is expected to provide a valuable educational experience.

凭借这一攻击奖，化学部的有机和大分子化学计划和多学科活动的国会议员办公室支持西拉斐特（Indiana），印第安纳州普渡大学化学系的Hilkka I. Kenttamaa博士和Lubrizol Corporiation的David Aaserud博士的工作。提出了一个涉及普渡大学和Lubrizol Corporation的高风险/高增强研究项目，用于研究光声解吸，作为将中性分子蒸发到质谱仪中的一种手段。目的是确定激光诱导的声学解吸（LIAD）与涉及质量选择试剂离子的气相离子 - 分子反应是否在热光谱表征的热光谱表征和/或非挥发性分子方面是否有益。初步实验证实了该概念的可行性，表现出高可预测性和可重复性，并提出了一些有趣的可能性。例如，将中性（非离子）非挥发性和/或热不稳定分子带入气相的能力将允许当前无法进行各种基本的热化学，结构和反应性研究。此外，这种简单的方法可以在定性分析中为Maldi提供有吸引力的补充。矩阵不需要必要，这可能会导致更好的可预测性。蒸发和电离事件的物理分离应允许使用许多不同类型的电离反应，从而为给定的分析物提供控制反应产物和热化学的控制，并访问各种信息。最后，这种方法应允许对当前不适合这种分析的某些化合物进行质谱表征。该奖项的Co-Pi David Aaserud将为拟议的工作提供5-10％的时间和资源，在那里他将共同为参与的研究生提供建议，并为该项目提供聚合物表征专业知识。互动将包括每月进度评论和在Lubrizol工作期间对一两个博士生的监督。学生将接触到Lubrizol的分析能力和工业环境。 Lubrizol将提供相关的样本并访问任何适当的其他分析信息，包括GPC，LC和NMR数据。在技​​术转移阶段，Lubrizol的实验室将适用于新技术在工业样本中的应用。 Lubrizol Corporation在数年内为肯塔玛教授实验室的研究生和研究项目提供了财政支持。 Lubrizol致力于继续作为部分或其成本分担。 Lubrizol认为合作努力是其与Kenttamaa教授的互动的延续，资源承诺的大幅度增加了。拟议的研究是在质谱研究中的前沿分子从固体阶段转移到气相的选择。卢布里唑对衍生多酰磷脂的兴趣源于以下事实：这些物质是许多润滑剂添加剂的重要组成部分。开发新的和更好的方法来表征烃聚合物及其功能化衍生物，将可以更好地了解这些材料，并有助于Lubrizol更好地预测产品性能。在有机和大​​分子化学计划和MPS多学科活动办公室的支持下，PI能够进行潜在的突破性研究，并与工业合作伙伴合作探索研究的现实世界应用。肯塔玛（Kenttamaa）教授有一大批女性和来自代表性不足的小组的本科生和研究生。对于他们来说，这项研究有望提供宝贵的教育经验。