CAREER: Studies of Pi-Pi Stacking Interactions in Small Molecules and Beta-Turn Peptides

职业：小分子和 β 转肽中 Pi-Pi 堆积相互作用的研究

• 批准号: 0094068
• 负责人: Marcey Waters
• 金额: $ 49.85万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-15 至 2006-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094068&HistoricalAwards=false
• 关键词: CAREER; Studies; Pi; Stacking; Interactions

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Marcey waters in the Department of Chemistry at the University of North Carolina at Chapel Hill. The work consists of a series of studies to better understand the role of pi-pi stacking interactions in macromolecular recognition in both DNA and proteins. She will measure the rate constants of rotation around biaryl bonds using NMR line-width analysis, and will also use NMR NOESY measurements to determine the extent of beta-sheet formation and assess pi-pi stacking interactions in a two stranded beta-peptide. These systems will probe the roles of electronic effects, solvent, surface area, and heteroatoms in the aromatic rings.The research and teaching goals of this proposal are to understand biological structure and reactivity through physical organic chemistry studies, particularly using nuclear magnetic resonance methods. The relationship between biological systems and nonbiological organic molecules will be emphasized at both graduate and undergraduate levels, including experiments in sophomore organic chemistry laboratory.

有了这个职业奖的有机和高分子化学计划支持博士Marcey沃茨在化学系在查佩尔山的北卡罗来纳州大学的工作。 这项工作包括一系列的研究，以更好地了解π-π堆积相互作用在DNA和蛋白质中的大分子识别中的作用。 她将使用NMR线宽分析测量联芳基键周围的旋转速率常数，还将使用NMR NOESY测量来确定β折叠形成的程度，并评估双链β肽中的π-π堆积相互作用。 该系统将探索电子效应、溶剂、表面积和芳环中杂原子的作用。本计划的研究和教学目标是通过物理有机化学研究，特别是使用核磁共振方法，了解生物结构和反应性。 生物系统和非生物有机分子之间的关系将在研究生和本科阶段强调，包括大二有机化学实验室的实验。