Cooperativity Driven Communication through Noncovalent Networks in Biomimetic Systems

仿生系统中通过非共价网络的协作驱动通信

基本信息

  • 批准号:
    2404149
  • 负责人:
  • 金额:
    $ 53万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2024
  • 资助国家:
    美国
  • 起止时间:
    2024-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

With the support of the Macromolecular, Supramolecular and Nanochemistry (MSN) Program in the Division of Chemistry, Professor Marcey Waters of the University of North Carolina (UNC) at Chapel Hill will develop new biomimetic model systems that imitate the complex behavior of proteins. This research aims to determine the molecular features that are necessary to create new stimulus-responsive molecules that mimic protein function, including molecular on-off switches for capturing/releasing other molecules, as well as self-assembly into nanospheres and nanofibers. This research seeks to provide better insight into protein function and provide guidelines for how to design new biomimetic "smart" materials. The broader impacts of this work will include interdisciplinary training for the students working on the project, as well as an outreach program to minority serving institutions that are part of the UNC system to build a network within North Carolina to promote pursuit of higher degrees in chemistry.Many proteins exhibit stimulus responsive behavior, as in allostery, conformational signaling, signal transduction, and complex protein assembly. These behaviors are accomplished via communication through a noncovalent network, but the molecular mechanisms of such communication are poorly understood. This research aims to provide fundamental insights into the design rules for biomimetic self-assembly and signal transduction, including their molecular and energetic requirements, as well as the role of both positive and negative cooperativity. Specifically, the Waters group will investigate the sequence-structure-assembly relationships in self-assembling coiled coil nanospheres and fibrils. An artificial signaling cascade will be developed for evaluation of the contribution of frustration in long-distance structural reorganization and responsive behavior of foldamers.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
在化学系大分子、超分子和纳米化学(MSN)项目的支持下,北卡罗来纳大学教堂山分校(UNC)的Marcey Waters教授将开发新的仿生模型系统,模仿蛋白质的复杂行为。这项研究旨在确定创造新的刺激反应分子所必需的分子特征,这些分子模拟蛋白质的功能,包括分子的开关,用于捕获/释放其他分子,以及自组装成纳米球和纳米纤维。这项研究旨在更好地了解蛋白质的功能,并为如何设计新的仿生“智能”材料提供指导。这项工作的更广泛影响将包括为参与该项目的学生提供跨学科培训,以及向北卡罗来纳大学系统内的少数民族服务机构提供外展计划,以在北卡罗来纳建立一个网络,促进对化学更高学位的追求。许多蛋白质表现出刺激反应行为,如变构、构象信号、信号转导和复杂蛋白质组装。这些行为是通过非共价网络的通信完成的,但这种通信的分子机制尚不清楚。本研究旨在为仿生自组装和信号转导的设计规则提供基本的见解,包括它们的分子和能量需求,以及正负合作的作用。具体来说,沃特斯团队将研究自组装线圈纳米球和原纤维的序列-结构-组装关系。将开发一个人工信号级联,以评估挫折对远距离结构重组和文件夹响应行为的贡献。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。

项目成果

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Marcey Waters其他文献

Marcey Waters的其他文献

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{{ truncateString('Marcey Waters', 18)}}的其他基金

Cooperativity Driven Communication through Noncovalent Networks in Biomimetic Systems
仿生系统中通过非共价网络的协作驱动通信
  • 批准号:
    2107685
  • 财政年份:
    2021
  • 资助金额:
    $ 53万
  • 项目类别:
    Standard Grant
REU Site: Summer Undergraduate Research Opportunity in Chemistry (SUROC) at UNC Chapel Hill
REU 网站:北卡罗来纳大学教堂山分校化学系暑期本科生研究机会 (SUROC)
  • 批准号:
    1757413
  • 财政年份:
    2018
  • 资助金额:
    $ 53万
  • 项目类别:
    Standard Grant
Development and Application of Synthetic Receptors for Methylated Lysine and Arginine for Methyltransferase Assays
用于甲基转移酶检测的甲基化赖氨酸和精氨酸合成受体的开发和应用
  • 批准号:
    1608333
  • 财政年份:
    2016
  • 资助金额:
    $ 53万
  • 项目类别:
    Standard Grant
Mechanistic Studies of Molecular Recognition of Methylated Lysine and Arginine
甲基化赖氨酸和精氨酸的分子识别机制研究
  • 批准号:
    1306977
  • 财政年份:
    2013
  • 资助金额:
    $ 53万
  • 项目类别:
    Continuing Grant
Development of Thioester Exchange for Generation and Screening of Cyclic Peptides for Nucleic Acid Recognition
用于核酸识别的环肽的生成和筛选的硫酯交换的发展
  • 批准号:
    1011794
  • 财政年份:
    2010
  • 资助金额:
    $ 53万
  • 项目类别:
    Standard Grant
Defining Tertiary Structure with Designed Beta-Hairpins
使用设计的 Beta 发夹结构定义三级结构
  • 批准号:
    0716126
  • 财政年份:
    2007
  • 资助金额:
    $ 53万
  • 项目类别:
    Continuing Grant
CAREER: Studies of Pi-Pi Stacking Interactions in Small Molecules and Beta-Turn Peptides
职业:小分子和 β 转肽中 Pi-Pi 堆积相互作用的研究
  • 批准号:
    0094068
  • 财政年份:
    2001
  • 资助金额:
    $ 53万
  • 项目类别:
    Continuing Grant

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