CAREER: Receptor Mediated Circular Dichroism Spectroscopy

通过这一职业奖，有机和高分子化学项目支持了密歇根州立大学东兰辛分校化学系的Babek Borhan博士的工作。本工作的目的是开发一组含有连接的四芳基卟啉锌配合物的主体分子，这些主体分子可以与客体手性Lewis碱(如胺)配位，从而使组装的圆二色谱指示碱的手性。所涉及的激子耦合圆二色谱(ECCD)给出了双符号CD光谱，其正负取决于相互作用的生色团的电跃迁偶极矩的绝对立体化学取向。Borhan希望开发一种光谱报告系统，可以用来快速确定手性有机化合物(镜像不同的化合物，如左手和右手)是左手还是右手。这种能力可能非常重要，特别是考虑到手性化合物在制药和生物学中的重要性。除了将参与这项研究的研究生，博尔汉博士还将建立一个美国化学协会附属的SEED项目，该项目将把来自经济困难家庭的高中生带到实验室进行暑期研究体验。

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Babek Borhan of the Department of Chemistry at Michigan State University in East Lansing, Michigan. The purpose of the work is to develop a set of host molecules, containing linked tetraaryl porphyrin zinc complexes, which can coordinate to a guest chiral Lewis base (such as an amine) in such a way that the circular dichroism spectrum of the assembly indicates the chirality of the base. The Exciton Coupled Circular Dichroism (ECCD) involved gives a bisignate CD spectrum, which is positive or negative depending only on the absolute stereochemical orientation of the electric transition dipole moment of the interacting chromophores.Dr. Borhan hopes to develop a spectroscopic reporting system which can be used to rapidly determine whether chiral organic compounds (compounds whose mirror images are different, like left and right hands) are left or right handed. This capability could be quite important, especially in view of the importance of chiral compounds in pharmaceuticals and biology. In addition to the graduate students who will be involved in the research, Dr. Borhan will establish an American Chemical Society affiliated SEED program, which will bring high school students from financially disadvantaged families into the lab for summer research experiences.