Chiral Halenium Ions for Enantioselective Chemical Processes

用于对映选择性化学过程的手性铪离子

• 批准号: 0957462
• 负责人: Babak Borhan
• 金额: $ 40.5万
• 依托单位: Michigan State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-15 至 2013-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0957462&HistoricalAwards=false
• 关键词: Chiral; Halenium; Ions; Enantioselective; Chemical

The aim of this project is to develop agents capable of delivering halenium ions such as chloride, bromide, and iodide, in a chiral fashion, such that the products obtained are enantiomerically enriched. Historically, this goal has not been met with great success for a variety of reasons, most importantly because of the fact that halenium ions are reactive and difficult to sequester, and thus background reactions compete effectively with "coordinated" halenium delivery. Nonetheless, recent success in the principal investigator's laboratory has led to the development of a strategy for taming the halenium ion for the halolactonization chemistry that affords products in high yield and high enantiomeric excess. This early success will be extended in a hypothesis driven manner for the application of chiral halenium ions to a large number of other reactions. With this award, the Chemical Synthesis program is supporting the research of Professor Babak Borhan of the Department of Chemistry at Michigan State University. Professor Borhan's research efforts revolve around the development of new enantio-selective methodologies that are facile, green, and economically feasible. The result of this work will expand the repertoire of enantioselective reactions to yield products of importance for the synthesis of biologically active agents and pharmaceuticals.

该项目的目的是开发能够以手性方式传递卤离子(如氯、溴和碘)的试剂，以便获得的产品具有对映体富集性。从历史上看，这一目标没有得到很大的成功，原因有很多，最重要的是因为卤离子是活泼的，很难被隔离，因此背景反应与“协调”的卤素传递有效地竞争。尽管如此，首席研究人员实验室最近的成功导致了一种驯服卤离子的策略，用于卤代内酯化学，提供高产率和高对映体过剩的产品。这一早期的成功将以假设驱动的方式扩展，将手性卤离子应用于大量其他反应。通过这一奖项，化学合成项目正在支持密歇根州立大学化学系巴布克·博尔汉教授的研究。博尔汉教授的研究工作围绕着开发简便、绿色和经济可行的新的对映选择性方法展开。这项工作的结果将扩大对映体选择性反应的范围，产生对合成生物活性物质和药物具有重要意义的产品。