CAREER: The Role of Amygdalocortical Systems in Affect and Attention

职业：杏仁皮质系统在情感和注意力中的作用

• 批准号: 0094377
• 负责人: Andrea Chiba
• 金额: $ 55万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0094377&HistoricalAwards=false
• 关键词: CAREER; Role; Amygdalocortical; Systems; Affect

Chiba abstractAn organism's ability to flexibly adapt its behavior based on the learned associations of environmental stimuli can be critical to the survival of that organism. Among other issues, successful adaptation relies on both appropriate modulation of attention and an accurate appraisal or evaluation of the affective significance of environmental stimuli. Two distinct anatomical divisions of the amygdala, the central nucleus and the basolateral complex, are thought to play a role in adaptive behavior under many experimental conditions that depend on associative learning. Numerous subcortical and cortical anatomical projections allow the amygdala access to basic sensory and somatic information, and also position it to affect the output of behavior. The proposed body of work is aimed towards the investigation of the role of the central nucleus and the basolateral complex of the amygdala and their constituent corticopetal/cortical systems in modulating attention and affective evaluation during learning. A combination of behavioral tasks, neural recording (single units) neurochemical manipulations, and lesion techniques will be used to gather data investigating these issues. Once the data are gathered, techniques for alternative analysis of the neural firing properties will be pursued in a collaborative effort with computational modelers.Additionally, this research program will be used as a vehicle to provide research opportunities for students at multiple academic levels (high school through post-doctoral). A critical component of this approach will include training researchers to do science while providing them with the skills and opportunities to teach others. Ultimately, this will result in a community outreach effort aimed towards providing unique scientific opportunities and information that may serve to draw a more diverse group of young people to the sciences.

千叶摘要一个有机体的能力，灵活地适应其行为的基础上学习协会的环境刺激可以是至关重要的生存有机体。 在其他问题中，成功的适应依赖于注意力的适当调节和对环境刺激的情感意义的准确评估或评价。 杏仁核的两个不同的解剖分区，中央核和基底外侧复合体，被认为在许多依赖于联想学习的实验条件下在适应性行为中发挥作用。 大量的皮质下和皮质解剖投射使杏仁核能够获得基本的感觉和躯体信息，并将其定位以影响行为的输出。 拟议的机构的工作是针对调查的作用，中央核和基底外侧复合体的杏仁核和其成分皮质/皮质系统在调节注意力和情感评价在学习过程中。 将使用行为任务、神经记录（单个单元）神经化学操作和损伤技术的组合来收集调查这些问题的数据。 一旦收集到数据，将与计算建模人员合作，寻求神经放电特性的替代分析技术。此外，该研究计划将用作为多个学术水平（高中到博士后）的学生提供研究机会的工具。 这一方法的一个关键组成部分将包括培训研究人员从事科学研究，同时为他们提供教授他人的技能和机会。 最终，这将产生一种社区外展努力，旨在提供独特的科学机会和信息，可能有助于吸引更多样化的青年群体参与科学。