What is the role of striatal dopamine in value-based decision-making?

纹状体多巴胺在基于价值的决策中发挥什么作用？

• 批准号: DP240103246
• 负责人: Prof Bernard Balleine
• 金额: $ 103.4万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2028-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240103246
• 关键词: What; role; striatal; dopamine; value

The aim of this project is to understand the role of dopamine in the brain circuits controlling goal-directed action. Its significance lies in our use of newly developed tools to measure dopamine release and cellular activity concurrently to assess the causal role of this interaction in choice and decision-making. The expected outcome of this project is to provide a comprehensive understanding of the role of dopamine release in striatal cellular activity and in the psychological processes mediating goal-directed decision-making. This outcome will have the benefit of filling a gap in our knowledge of the brain processes mediating decision-making, a fundamental capacity that contributes to our physical and psychological wellbeing (wellness).

该项目的目的是了解多巴胺在控制目标指导作用的大脑电路中的作用。它的意义在于我们使用新开发的工具来测量多巴胺释放和细胞活性同时评估这种相互作用在选择和决策中的因果作用。该项目的预期结果是对多巴胺释放在纹状体细胞活性以及介导目标指导决策的心理过程中的作用进行全面了解。这种结果将有利于填补我们对介导决策的大脑过程的差距，这是有助于我们的身体和心理健康（健康）的基本能力。