CONFERENCE: Junior Investigator Participation in FASEB Conference on Biological Methylation to be held from July 21-26, 2001, at the Vermont Academy in Saxtons River, Vermont

这笔赠款用于资助年轻研究人员参加将于2001年7月21-26日在佛蒙特州萨克斯顿河举行的2001年美国实验生物学联合会(FASE B)生物甲基化夏季研究会议。这次会议是始于1993年的一系列两年一度的会议中的第五次，会议由金融、经济及社会理事会主办。这些会议是为了满足召开会议的需要，会议的重点是S-腺苷蛋氨酸(ADOMet)，大多数生物甲基化反应的甲基供体，以及细胞中各种依赖ADOMet的反甲基化反应。2001年会议的大约一半会议将集中讨论DNA甲基化，因为DNA甲基化已被证明在基因表达、印记和肿瘤发生的调节中发挥重要作用。会议将讨论的其他议题包括ADOMet与人类健康、与衰老和基因表达有关的各种蛋白质甲基化反应，以及在化疗中重要的小分子甲基化反应。这次会议为对ADOMet甲基化和ADOMet代谢各个方面感兴趣的科学家提供了一个独特的互动机会，这是任何其他会议都没有实现的。因此，这次会议传统上为富有成效的合作提供了起点。与会者的专业知识差异很大，从合成化学到分子生物学，再到生理学和医学。

This grant provides support for young investigators to attend the 2001 Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Biological Methylation to be held on July 21-26, 2001, in Saxton River, VT. This conference is the fifth in a series of biennial conferences that began in 1993, under the auspices of the FASEB. These conferences were organized in response to the need for a conference with a focus on S-adenosylmethionine (AdoMet), the methyl donor for most biological methylation reactions, and the various AdoMet-dependent transmethylation reactions in cells. Approximately half of the 2001 meeting's sessions will be focused on the methylation of DNA, as DNA methylation has been shown to play important roles in the regulation of gene expression, imprinting and tumorigenesis. Other topics to be discussed at the meeting include the AdoMet and human health, various protein methylation reactions involved in aging and gene expression, and small molecule methylation reactions important in chemotherapy. This Conference provides a unique opportunity for scientists interested in various aspects of AdoMet methylation and AdoMet metabolism to interact, which is not achieved at any other conference. Consequently, this meeting has traditionally provided the starting point for productive collaborations. The expertise of attendees varies widely, ranging from synthetic chemistry to molecular biology to physiology and medicine.