RUI: Acquisition of a DNA Microarray Reader System

0099720营该奖项支持购买DNA微阵列读取器和支持设备。该设备是研究酵母和其他生物基因组中发现的所有基因同时表达所必需的。这种对全基因组表达的分析通常被称为功能基因组学；购买和操作功能基因组学所需的设备的成本足够高，通常超出了单一本科院校的能力范围。通过该奖项购买的设备虽然位于一家机构，但将提供给全国各地希望从事此类研究但目前无法获得必要设备的大学教职员工联盟。通过该设备进行的研究包括老化和DNA结合化学物质对酵母基因表达的影响的研究。此外，几个参与的教员将合作开发新的算法，用于DNA微阵列数据集的数学分析。用户是23名教职员工(来自美国和加拿大)的成员，他们成立了主动教学基因组联盟(GCAT)。在2000-2001学年，GCAT将使用酵母DNA微阵列协调一系列功能基因组学实验，这些微阵列可以使用本奖项提供的设备进行测量。预计研究工作将对生物学这一重要领域的本科生培训(包括妇女和代表性不足的少数群体)产生重大影响。

0099720CampbellThis award supports acquisition of a DNA microarray reader and supporting equipment. The equipment is required for studies of the simultaneous expression of all genes found in the genomes of yeast and other organisms. Such analysis of whole genome expression is usually referred to as functional genomics; the cost of purchasing and operating the equipment needed for functional genomics is high enough that it is generally beyond the means of single undergraduate institution. The equipment purchased through this award, though located at one institution, will be available to a consortium of college faculty from across the country who desire to pursue such research, but currently lack access to the necessary equipment. Research to be enabled by the equipment includes studies of the effect of aging and of DNA-binding chemicals on gene expression in yeast. In addition, several participating faculty will collaborate on an effort to develop new algorithms for mathematical analysis of DNA microarray datasets. The users are members of a group of 23 faculty (from the US and Canada) who have formed the Genome Consortium for Active Teaching (GCAT). During the 2000-2001 academic year, GCAT will coordinate a series of functional genomics experiments using yeast DNA microarrays that can be measured using the equipment provided through this award. The research efforts are expected to have a substantial impact on undergraduate training (including that of women and underrepresented minorities) in an area of biology of major importance.