Information Transfer in the Mammalian Circadian Clock

哺乳动物昼夜节律钟的信息传递

• 批准号: 149402905
• 负责人: Professor Dr. Hanspeter Herzel
• 金额: --
• 依托单位: Fachbereich Chronobiologie (CVK)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2015-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/149402905?language=en
• 关键词: Information; Transfer; Mammalian; Circadian; Clock

Most species evolved a circadian clock to adapt to the 24 h period of the solar day. In mammals, these clocks generate endogeneous rhythms by regulatory gene networks in almost every cell. A pacemaker, the suprachiasmatic nucleus (SCN) as the master clock, receives light input and orchestrates peripheral organs via sympathetic enervation, temperature and humoral factors. In our project we address the following questions: How is information of Zeitgeber signals encoded in cellular and behavioral rhythms? How do networks of noisy SCN cells reliably transmit light input to output rhythms? What are the transcriptional regulations allowing communication from the SCN to peripheral organs? To address these questions we combine experimental data from single cells, organotypic slices and behavioral activity rhythms with mathematical models of coupled oscillators. Moreover, with bioinformatic methods we study the combinatorial and epigenetic regulations of clockcontrolled genes.

大多数物种进化出了生物钟来适应太阳日的 24 小时周期。在哺乳动物中，这些生物钟通过几乎每个细胞中的调节基因网络产生内源节律。作为起搏器的视交叉上核（SCN）作为主时钟，接收光输入并通过交感神经衰弱、温度和体液因素协调外周器官。在我们的项目中，我们解决了以下问题：Zeitgeber 信号的信息如何编码在细胞和行为节律中？嘈杂的 SCN 细胞网络如何可靠地将光输入传输到输出节律？允许从 SCN 到外周器官通讯的转录调控是什么？为了解决这些问题，我们将来自单细胞、器官切片和行为活动节律的实验数据与耦合振荡器的数学模型结合起来。此外，通过生物信息学方法，我们研究时钟控制基因的组合和表观遗传调控。