SBIR Phase I: BioTELL - A Novel Biosensor for Microbes

SBIR 第一阶段：BioTELL - 一种新型微生物生物传感器

• 批准号: 0109792
• 负责人: Karolyn Hansen
• 金额: $ 10万
• 依托单位: QGENICS Biosciences, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0109792&HistoricalAwards=false
• 关键词: SBIR; Phase; BioTELL; Novel; Biosensor

This Small Business Innovation Research (SBIR) Phase I project will test new methods to detect and distinguish similar strains of the bacteria Haemophilus influenzae. Ninety-five percent of systemic infections in childhood are caused by H. influenzae strains of the serotype b. They include meningitis, sepsis, epiglottitis, pneumonia and otitis media. Bacterial meningitis and epiglottitis are life-threatening diseases with a lethality of five percent to twenty-five percent. Thus, a real-time sensor capable of detecting specific strains of H. influenzae in the parts-per-trillion range is needed. Any new detection device must be highly sensitive and selective, miniature, self-diagnostic, low cost, have rapid response time, and require no sample preparation. This Phase I project proposes such a novel point-of-care detection device for highly sensitive determination of H. influenzae and other bacteria strains. This approach builds on recent research conducted at Oak Ridge National Laboratory using microcantilevers as sensor platforms. The BioTELL sensor will consist of an array of microcantilevers with one surface derivatized by an antibody coating receptive to H. influenzae antigens.The commercial applications of this project will be in the biosensor market for detection of H. influenzae and other disease causing microorganisms. The primary customers for products developed through this project are expected to include pediatricians, general practitioners and consumer households.

这个小企业创新研究（SBIR）第一阶段项目将测试新的方法来检测和区分流感嗜血杆菌的类似菌株。95%的儿童全身感染是由H。血清型B的流感病毒株。它们包括脑膜炎、败血症、会厌炎、肺炎和中耳炎。细菌性脑膜炎和会厌炎是危及生命的疾病，致死率为5%至25%。因此，能够检测H.需要万亿分之几的流感病毒。任何新的检测设备都必须具有高灵敏度和选择性、微型、自诊断、低成本、快速响应时间和无需样品制备。该I期项目提出了一种用于高灵敏度测定H的新型即时检测设备。流感和其他细菌菌株。这种方法建立在橡树岭国家实验室最近进行的研究基础上，使用微悬臂梁作为传感器平台。BioTELL传感器将由一个微悬臂梁阵列组成，其一个表面由接受H的抗体涂层衍生。本项目的商业应用将是在生物传感器市场上用于检测H。流感和其它致病微生物。通过该项目开发的产品的主要客户预计将包括儿科医生，全科医生和消费者家庭。