RUI - Acquisition of a Circular Dichroism Spectropolarimeter

RUI - 购买圆二色性分光偏振计

• 批准号: 0116741
• 负责人: Lisa Hibbard
• 金额: $ 9.79万
• 依托单位: Spelman College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0116741&HistoricalAwards=false
• 关键词: RUI; Acquisition; Circular; Dichroism; Spectropolarimeter

ACQUISITION OF A CIRCULAR DICHROISM SPECTROPOLARIMETERNSF Proposal #0116741ABSTRACT A grant has been awarded to Dr. Lisa Hibbard at Spelman College to fund the acquisition of a circular dichroism (CD) spectropolarimeter to be used for the following purposes: (1) The PIs current project involves a study of the structure and function of the eye lens protein a-crystallin using spectroscopy techniques. (2) The Chemistry Department will perform protein structure determination experiments in the teaching biochemistry laboratory course. (3) It will be used in a spectroscopy laboratory-based course that is proposed as a bridging course between the departments of Chemistry and Physics at the College. (4) There will be occasional use by researchers at Clark-Atlanta University who are collaborators with faculty at Spelman College. The research project is of significance as there is still a great deal to be learned regarding the relationship between a-crystallin structure and chaperone function. Little information is currently available on the tertiary structure of the protein and no one has studied the effects of the presence of salt in conjunction with exposure to UV radiation on structure and function. In addition, as Spelman College prides itself on producing excellent African-American women scientists, these projects will serve as a training ground for undergraduate students to perform biochemical research. The CD instrument will also be available for use in teaching lab experiments in the Chemistry and Physics Departments at Spelman and by other researchers in the Atlanta area. Students from underrepresented groups will be exposed to new technologies through courses, laboratories, and research projects utilizing this new instrument.

获得圆二色性分光偏振计NSF提案#0116741摘要Spelman学院的丽莎希巴德博士获得了一笔赠款，用于购买圆二色性（CD）分光偏振计，用于以下目的：（1）PI目前的项目涉及使用光谱技术研究眼睛透镜蛋白a-晶状体蛋白的结构和功能。(2)化学系将在生物化学实验室课程教学中进行蛋白质结构测定实验。(3)它将被用于光谱实验室为基础的课程，被提议作为在学院的化学和物理系之间的桥梁课程。(4)克拉克-亚特兰大大学的研究人员偶尔会与斯佩尔曼学院的教师合作。 该研究项目具有重要意义，因为关于α-晶体蛋白结构和伴侣蛋白功能之间的关系还有很多东西要了解。 目前关于蛋白质三级结构的信息很少，也没有人研究盐的存在与紫外线辐射对结构和功能的影响。 此外，由于斯佩尔曼学院以培养优秀的非洲裔美国女科学家而自豪，这些项目将成为本科生进行生物化学研究的训练基地。 CD仪器也将用于斯佩尔曼化学和物理系以及亚特兰大地区其他研究人员的教学实验室实验。来自代表性不足群体的学生将通过利用这种新仪器的课程，实验室和研究项目接触新技术。