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MRI: Acquisition of a Circular Dichroism Spectrometer for Research and Training at St. Mary's College of Maryland

MRI：购买圆二色性光谱仪用于马里兰州圣玛丽学院的研究和培训

基本信息

批准号：
1919581
负责人：
Shanen Sherrer
金额：
$ 12.18万
依托单位：
St Mary's College of Maryland
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-10-01 至 2021-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919581&HistoricalAwards=false
关键词：
MRI Acquisition Circular Dichroism Spectrometer

项目摘要

An award is made to St. Mary's College of Maryland to purchase a circular dichroism (CD) spectrometer for collaborative research. This instrument monitors rotational change in circular polarized light as it passes through a sample with chirality, which a common property of biological, inorganic and organic materials. Faculty and students will use the CD spectrometer to probe macromolecular structural characteristics of soil organic matter, polymers and biomolecular interactions, and to examine changes to chemical properties under specific experimental conditions. This instrument will facilitate scholarly and instructional collaborations across disciplines and significantly enhance the college's infrastructure by providing new technology for quantitative analysis. It also will contribute towards the college's curricular transformations associated with participation in the multi-year Council for Undergraduate Research Transformations Project (NSF-DUE #1625354), which aims to integrate research activities into the undergraduate STEM curriculum to enhance student learning and better position students for success in the professional and academic arenas. The research projects facilitated with the CD spectrometer will address important societal issues including carbon cycling, pollutant fate and transport in the environment, the impact of emerging contaminants like endocrine disruptors on marine invertebrates, development of clean tight-gas extraction methods, and heavy metal exposure. CD spectroscopic studies at the college will augment and enhance current and future work by allowing faculty and student researchers to use the instrument to provide the following: (a) direct evidence of molecular interactions within DNA damage tolerance and repair systems; (b) improvement of molecular design of small molecule inhibitors for biological targets; (c) elucidation of structural thermodynamics of proteins in an avian endocrine system; (d) exploration of protein conformations and metal ion coordination geometry of metal-organic complexes; and (e) examination of ion behavior, structural changes and interactions of clay during uptake of fluid species in different thermochemical environments. Results from experiments using the CD spectrometer will benefit a broad range of research fields, from geochemical processes to molecular mechanisms of DNA repair in biological systems to whole organism physiology in oysters and birds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

马里兰州圣玛丽学院被授予购买一台圆二色(CD)光谱仪用于合作研究。该仪器监测圆偏振光通过具有手性的样品时的旋转变化，手性是生物、无机和有机材料的常见特性。教师和学生将使用CD光谱仪探索土壤有机质、聚合物和生物分子相互作用的大分子结构特征，并检查特定实验条件下化学性质的变化。这一工具将促进跨学科的学术和教学合作，并通过为定量分析提供新技术来显著增强学院的基础设施。它还将通过参与多年期本科生研究转型理事会项目(国家科学基金会-到期编号1625354)，促进学院的课程转型，该项目旨在将研究活动纳入本科生STEM课程，以加强学生的学习，并使学生更好地为在专业和学术领域取得成功奠定基础。利用CD光谱仪推动的研究项目将解决重要的社会问题，包括碳循环、污染物在环境中的去向和迁移、内分泌干扰物等新出现的污染物对海洋无脊椎动物的影响、清洁密闭气体提取方法的开发以及重金属暴露。学院的圆二色谱研究将增加和加强目前和未来的工作，使教职员工和学生研究人员能够利用该仪器提供下列内容：(A)直接证明DNA损伤容忍和修复系统内的分子相互作用；(B)改进用于生物靶标的小分子抑制剂的分子设计；(C)阐明鸟类内分泌系统中蛋白质的结构热力学；(D)探索金属-有机络合物的蛋白质构象和金属离子配位几何；以及(E)研究不同热化学环境中流体物种吸收过程中粘土的离子行为、结构变化和相互作用。使用CD光谱仪的实验结果将惠及广泛的研究领域，从地球化学过程到生物系统中DNA修复的分子机制，再到牡蛎和鸟类的整体生物体生理学。这一奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。