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MRI: Acquisition of a Circular Dichroism Spectrometer for Research and Training at St. Mary's College of Maryland

MRI：购买圆二色性光谱仪用于马里兰州圣玛丽学院的研究和培训

基本信息

批准号：
1919581
负责人：
Shanen Sherrer
金额：
$ 12.18万
依托单位：
St Mary's College of Maryland
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-10-01 至 2021-09-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919581&HistoricalAwards=false
关键词：
MRI Acquisition Circular Dichroism Spectrometer

项目摘要

An award is made to St. Mary's College of Maryland to purchase a circular dichroism (CD) spectrometer for collaborative research. This instrument monitors rotational change in circular polarized light as it passes through a sample with chirality, which a common property of biological, inorganic and organic materials. Faculty and students will use the CD spectrometer to probe macromolecular structural characteristics of soil organic matter, polymers and biomolecular interactions, and to examine changes to chemical properties under specific experimental conditions. This instrument will facilitate scholarly and instructional collaborations across disciplines and significantly enhance the college's infrastructure by providing new technology for quantitative analysis. It also will contribute towards the college's curricular transformations associated with participation in the multi-year Council for Undergraduate Research Transformations Project (NSF-DUE #1625354), which aims to integrate research activities into the undergraduate STEM curriculum to enhance student learning and better position students for success in the professional and academic arenas. The research projects facilitated with the CD spectrometer will address important societal issues including carbon cycling, pollutant fate and transport in the environment, the impact of emerging contaminants like endocrine disruptors on marine invertebrates, development of clean tight-gas extraction methods, and heavy metal exposure. CD spectroscopic studies at the college will augment and enhance current and future work by allowing faculty and student researchers to use the instrument to provide the following: (a) direct evidence of molecular interactions within DNA damage tolerance and repair systems; (b) improvement of molecular design of small molecule inhibitors for biological targets; (c) elucidation of structural thermodynamics of proteins in an avian endocrine system; (d) exploration of protein conformations and metal ion coordination geometry of metal-organic complexes; and (e) examination of ion behavior, structural changes and interactions of clay during uptake of fluid species in different thermochemical environments. Results from experiments using the CD spectrometer will benefit a broad range of research fields, from geochemical processes to molecular mechanisms of DNA repair in biological systems to whole organism physiology in oysters and birds.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

授予马里兰州的圣玛丽学院购买一台圆二色性（CD）光谱仪进行合作研究。该仪器监测圆偏振光通过手性样品时的旋转变化，手性是生物，无机和有机材料的共同特性。教师和学生将使用CD光谱仪探测土壤有机质，聚合物和生物分子相互作用的大分子结构特征，并检查在特定实验条件下化学性质的变化。该仪器将促进跨学科的学术和教学合作，并通过提供定量分析的新技术来显着增强学院的基础设施。它还将有助于学院的课程转型与参与多年理事会本科研究转型项目（NSF-DUE #1625354），其目的是将研究活动整合到本科STEM课程，以提高学生的学习和更好地定位学生在专业和学术领域的成功。CD光谱仪促进的研究项目将解决重要的社会问题，包括碳循环，环境中的污染物命运和运输，新兴污染物（如内分泌干扰物）对海洋无脊椎动物的影响，清洁密闭气体提取方法的开发以及重金属暴露。该学院的CD光谱研究将通过允许教师和学生研究人员使用该仪器提供以下内容来增强和加强当前和未来的工作：（a）DNA损伤耐受性和修复系统内分子相互作用的直接证据;（B）改进生物靶点的小分子抑制剂的分子设计;（c）阐明鸟类内分泌系统中蛋白质的结构热力学;（d）研究鸟类内分泌系统中蛋白质的结构热力学。（d）探索蛋白质构象和金属-有机络合物的金属离子配位几何结构;以及（e）研究粘土在不同热化学环境中吸收流体物种期间的离子行为、结构变化和相互作用。从地球化学过程到生物系统中DNA修复的分子机制，再到牡蛎和鸟类的整个生物体生理学，使用CD光谱仪进行的实验结果将使广泛的研究领域受益。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。