SGER: Nanostructured Drug Delivery Systems

SGER：纳米结构药物输送系统

• 批准号: 0118705
• 负责人: Jackie Ying
• 金额: $ 10万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0118705&HistoricalAwards=false
• 关键词: SGER; Nanostructured; Drug; Delivery; Systems

AbstractCTS-0118705Jackie Ying, MITIt is proposed to investigate the design feasibility of an intelligent drug delivery system. Its design would be based on nanometer components organized into mass, surface and chemistry distributions which will optimize the delivery, while adapting to the nature of its body environment. Such would be the delivery of insulin with a synthetic carrier nanodevice, which would typically protect the insulin load from gastrointestinal acidity, and also have an adaptive chemical distribution which will release the contained insulin when the carrier would reach a part of the flow showing predetermined ambient chemical properties.

中文摘要本论文旨在探讨一种智能药物输送系统的设计可行性。 其设计将基于纳米组分，这些组分被组织成质量、表面和化学分布，这将优化递送，同时适应其身体环境的性质。 这将是用合成载体纳米装置递送胰岛素，其通常将保护胰岛素负荷免受胃肠道酸度的影响，并且还具有自适应化学分布，当载体将到达显示预定环境化学性质的流的一部分时，该自适应化学分布将释放所包含的胰岛素。