FOR 1368: Hemodynamic Mechanisms of Acute Kidney Injury

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The Research Unit consists of eight research groups with different methodological expertise and a long-standing history of collaborations. Acute kidney injury (AKI) comprises a family of syndromes characterised by a sudden decrease in glomerular filtration rate. A multitude of causes may lead to acute kidney injury, which are commonly classified according to their origin as intrarenal, pre- and postrenal. The damage leading to acute kidney injury spans from functional dysregulation without overt morphological features to tubular destruction. Considerable effort has been made to develop techniques to prevent acute kidney injury or to facilitate its resolution. Unfortunately, preventing the development of AKI in at-risk populations is difficult. By true collaborative and translational research with interactions between the eight groups we pursue the following goals: (1) to define the role of regional circulation, particularly the vasa afferentia and vasa efferentia, and the role of TRPV1 in the pathophysiology of acute kidney injury; (2) to elucidate the mechanisms of AKI-induced stimulation of Hypoxia inducible factor (HIF), cytochrome P450 (CYP) products and NF-B; (3) to establish a promising marker for acute kidney injury and its origin; (4) to define a new strategy to prevent or treat acute kidney injury caused by local ischemia. As a whole, this Research Unit aims at transferring new insights from the pathophysiology of acute kidney injury into prevention strategies to reduce morbidity and mortality.