U.S.-Sweden Cooperative Research: Microfabricated Receptors by Combinatorial Imprinting in Aqueous Media

[122964]该奖项支持闫明迪和波特兰州立大学的学生与瑞典斯德哥尔摩皇家理工学院有机化学系的Olof Ramstrom的合作。该项目将专注于合成和在水溶液中使用定制的聚合物受体的困难任务，这些受体能够选择性地识别配体结构的微小差异。新的化学和制造技术将应用于分子印迹以应对这一挑战，这在生物学应用中是至关重要的。印迹化学采用可逆的，但稳定的化学键，可以在水环境中存活。毛细管微成型技术将用于分子印迹聚合物的合成。同样的技术将使完成这些聚合物文库的合成成为可能，这些文库可以用于筛选最佳的印迹化学以及生物分析。该项目的长期目标是将组合分子印迹聚合物的合成和分析集成到单个芯片上，并基于微制造阵列构建多分析物传感器。

0122964YanThis award supports Mingdi Yan and students from Portland State University in a collaboration with Olof Ramstrom of the Department of Organic Chemistry at the Royal Institute of Technology in Stockholm, Sweden. The project will focus on the difficult tasks of synthesis and use of in aqueous solutions of tailor-made polymeric receptors that are capable of selectively recognizing small differences in ligand structure. New chemistry and fabrication techniques will be applied to molecular imprinting in order to meet the challenge, which is of utmost importance in biological applications. The imprinting chemistry employs reversible, but stable bonds that survive the water environment. The technique of micromoulding in capillary will be used for the synthesis of molecularly imprinted polymers. The same technique will make it possible to accomplish the synthesis of libraries of such polymers that can be screened for optimal imprinting chemistry as well as for biological assays. The long-term goals of the project are to integrate the synthesis and analysis of combinatorial molecularly imprinted polymers on a single chip and to construct multi-analyte sensors based on the microfabricated arrays.