U.S.-Sweden Cooperative Research: Microfabricated Receptors by Combinatorial Imprinting in Aqueous Media

0122964 Yan该奖项支持来自波特兰州立大学的Yan Mingdi和学生与瑞典斯德哥尔摩皇家理工学院有机化学系的Olof Ramstrom合作。 该项目将侧重于合成和使用定制的聚合物受体的水溶液中的困难任务，这些受体能够选择性地识别配体结构中的微小差异。 新的化学和制造技术将被应用于分子印迹，以应对挑战，这在生物应用中至关重要。 印迹化学采用可逆的，但稳定的键，生存的水环境。 毛细管微模塑技术将用于分子印迹聚合物的合成。 相同的技术将使得有可能完成这样的聚合物的文库的合成，所述聚合物的文库可以被筛选用于最佳印迹化学以及用于生物测定。 该项目的长期目标是在单个芯片上集成组合分子印迹聚合物的合成和分析，并构建基于微加工阵列的多分析物传感器。

0122964YanThis award supports Mingdi Yan and students from Portland State University in a collaboration with Olof Ramstrom of the Department of Organic Chemistry at the Royal Institute of Technology in Stockholm, Sweden. The project will focus on the difficult tasks of synthesis and use of in aqueous solutions of tailor-made polymeric receptors that are capable of selectively recognizing small differences in ligand structure. New chemistry and fabrication techniques will be applied to molecular imprinting in order to meet the challenge, which is of utmost importance in biological applications. The imprinting chemistry employs reversible, but stable bonds that survive the water environment. The technique of micromoulding in capillary will be used for the synthesis of molecularly imprinted polymers. The same technique will make it possible to accomplish the synthesis of libraries of such polymers that can be screened for optimal imprinting chemistry as well as for biological assays. The long-term goals of the project are to integrate the synthesis and analysis of combinatorial molecularly imprinted polymers on a single chip and to construct multi-analyte sensors based on the microfabricated arrays.