U.S.-Sweden Cooperative Research: Characterization of Novel Bradykinin Receptors in the Gastrointestinal Tracts of Trout and Cod

美国-瑞典合作研究：鳟鱼和鳕鱼胃肠道中新型缓激肽受体的表征

• 批准号: 9732434
• 负责人: J. Michael Conlon
• 金额: $ 1.7万
• 依托单位: Creighton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-01 至 2001-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9732434&HistoricalAwards=false
• 关键词: U.S.; Sweden; Cooperative; Research; Characterization

9732434ConlonThis award will support Michael ConlonI and two graduate students from Creighton University in cooperative research with Suzanne Holmgren and J÷rgen Jensen of the Department of Zoophysiology at the University of G÷teborg, Sweden. The research will identify an antagonist to the peptide bradykinin, which is produced in teleost fish such as the rainbow trout and Atlantic cod. The results will shed light on the evolution of the peptide system, and will also further understanding of the action of pharmacological substances associated with bradykinin effects in mammalian systems.

该奖项将支持迈克尔·康洛尼和克雷顿大学的两名研究生与瑞典德堡大学动物生理学系的苏珊娜·霍尔姆格伦和Júrgen Jensen进行合作研究。这项研究将确定一种对缓激肽的拮抗剂，缓激肽是在彩虹鲑鱼和大西洋鳕鱼等硬骨鱼中产生的。这一结果将有助于揭示多肽系统的进化，也将进一步了解与缓激肽效应相关的药理物质在哺乳动物系统中的作用。