Enhancement of the Organic Chemistry Laboratory Curriculum Using Temperature-Programmable, Computer-Controlled, and Network -Accessible Gas Chromatographs

化学(12)我们正在使用配备TCD检测器的可编程温度的计算机控制的气相色谱仪(GC)来提炼、调整和整合一般和有机化学序列中的一套全面的实验。计算机控制的GC的吞吐量增加，使您可以在校园内联网的任何地方访问所采集的数据和强大的数据分析软件。这些实验将我们创新的普通化学和化学平衡探究驱动模式扩展到有机化学。作为我们当前关于脂肪和营养的专题模块的一部分，学生们首先通过脂肪和油的分析向学生介绍普通化学中的GC仪器。在有机序列中，几个关键的实验是由个别学生以调查的、假设的方式进行的。例如，学生通过观察不同溶剂、烯烃和氢硼化试剂的影响来详细检查氢化反应的条件和机理细节。在另一项实验中，学生们比较了消除2-溴丁烷的E1和E2，得到顺式和反式-2-丁烯。由于异构体可以被GC系统拆分，因此相对产率导致了对机理的深入了解。最后，GC还被用于一门关于香水的跨学科课程，以及霍华德·休斯资助的“科学中的女孩和女性”项目的社区外联活动，在该项目中，六年级女孩和她们的老师对汽油和其他常见材料进行“亲身实践”的GC分析。我们正在由一名化学教育现场专家对该项目进行全面评估。我们将通过NSF资助的ChemLinks联盟的网站和链接，以及《化学教育杂志》上的文章，在全国范围内传播该项目的结果。

Chemistry (12)We are using temperature-programmable, computer-controlled gas chromatographs (GCs) equipped with TCD detectors to refine, adapt and incorporate a comprehensive set of experiments in the general and organic chemistry sequences. The enhanced throughput of the computer-controlled GCs provides access to the acquired data and powerful data analysis software anywhere on the campus intranet. The experiments extend our innovative inquiry-driven model for General Chemistry and Chemical Equilibrium to Organic Chemistry. Students are first introduced to GC instrumentation in General Chemistry through an analysis of fats and oils as part of our current topical module on fats and nutrition. In the Organic sequence, several key experiments are run in an investigative, "what if" fashion by individual students. For example, detailed examination of the conditions and mechanistic details of the hydroboration reaction by observing the effect of different solvents, alkenes, and hydroboration reagents are investigated by students. In another experiment, students compare E1 vs. E2 elimination of 2-bromobutane to give cis- and trans-2-butene. Since the isomers can be resolved by the GC system, the relative yields lead to insights about the mechanism. Finally, the GCs are also being used in an inter-disciplinary course on perfumes and in community outreach activities in a Howard Hughes-funded program for "Girls and Women in Science," where sixth grade girls and their teachers perform "hands-on" GC analyses of gasoline and other common materials. We are carrying a comprehensive assessment of the project by an on-site specialist in chemical education. We will disseminate the results of the project nationally through the web sites and links to the NSF-funded ChemLinks Coalition, as well as through articles in The Journal of Chemical Education once they become available.