Enhancement of the Organic Chemistry Laboratory Curriculum Using Temperature-Programmable, Computer-Controlled, and Network -Accessible Gas Chromatographs

使用温度可编程、计算机控制和网络可访问的气相色谱仪增强有机化学实验室课程

• 批准号: 0126580
• 负责人: Laura Parmentier
• 金额: $ 3.83万
• 依托单位: Beloit College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-15 至 2004-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0126580&HistoricalAwards=false
• 关键词: Enhancement; Organic; Chemistry; Laboratory; Curriculum

Chemistry (12)We are using temperature-programmable, computer-controlled gas chromatographs (GCs) equipped with TCD detectors to refine, adapt and incorporate a comprehensive set of experiments in the general and organic chemistry sequences. The enhanced throughput of the computer-controlled GCs provides access to the acquired data and powerful data analysis software anywhere on the campus intranet. The experiments extend our innovative inquiry-driven model for General Chemistry and Chemical Equilibrium to Organic Chemistry. Students are first introduced to GC instrumentation in General Chemistry through an analysis of fats and oils as part of our current topical module on fats and nutrition. In the Organic sequence, several key experiments are run in an investigative, "what if" fashion by individual students. For example, detailed examination of the conditions and mechanistic details of the hydroboration reaction by observing the effect of different solvents, alkenes, and hydroboration reagents are investigated by students. In another experiment, students compare E1 vs. E2 elimination of 2-bromobutane to give cis- and trans-2-butene. Since the isomers can be resolved by the GC system, the relative yields lead to insights about the mechanism. Finally, the GCs are also being used in an inter-disciplinary course on perfumes and in community outreach activities in a Howard Hughes-funded program for "Girls and Women in Science," where sixth grade girls and their teachers perform "hands-on" GC analyses of gasoline and other common materials. We are carrying a comprehensive assessment of the project by an on-site specialist in chemical education. We will disseminate the results of the project nationally through the web sites and links to the NSF-funded ChemLinks Coalition, as well as through articles in The Journal of Chemical Education once they become available.

化学（12）我们正在使用温度可编程，计算机控制的气相色谱仪（GC）配备TCD检测器，以完善，调整和纳入一套全面的实验，在一般和有机化学序列。计算机控制的GC的增强的吞吐量提供了在校园内联网的任何地方访问所获得的数据和强大的数据分析软件。这些实验将我们的创新探究驱动模型扩展到普通化学和化学平衡到有机化学。学生首先介绍了一般化学通过分析脂肪和油的GC仪器作为我们目前的脂肪和营养专题模块的一部分。在有机序列中，几个关键的实验是在一个调查性的，“如果”的时尚由个别学生运行。例如，通过观察不同溶剂，烯烃和硼氢化试剂的效果，详细检查硼氢化反应的条件和机理细节。在另一个实验中，学生比较E1与E2消除2-溴丁烷得到顺式和反式-2-丁烯。由于异构体可以通过GC系统解析，因此相对产率导致对机理的了解。最后，GC还被用于一个关于香水的跨学科课程，以及霍华德休斯资助的“科学中的女孩和妇女”项目的社区外展活动，在该项目中，六年级的女孩和她们的老师对汽油和其他常见材料进行“动手”GC分析。我们正在由化学教育方面的现场专家对该项目进行全面评估。我们将通过网站和链接到NSF资助的ChemLinks联盟，以及通过《化学教育杂志》上的文章在全国范围内传播该项目的结果。