Integrating Hands-On Access to High Field NMR Across the Undergraduate Chemistry Curriculum

在本科化学课程中整合高场核磁共振的动手实践

• 批准号: 0126678
• 负责人: Louis Liotta
• 金额: $ 10.86万
• 依托单位: Stonehill College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0126678&HistoricalAwards=false
• 关键词: Integrating; Hands; Access; Field; NMR

Chemistry (12)Stonehill College is integrating high field FT-NMR across the entire chemistry curriculum in order to strengthen the ability of students to retain what they learn, draw connections between courses, interpret spectroscopic results, and design experiments. This project is impacting chemistry, biochemistry, biology, environmental studies, and computer engineering majors. The incorporation of high field FT-NMR across the entire curriculum is based on NSF-DUE funded projects (Nolen-DUE008827, Smart-DUE0087655, Wallace-DUE9952343, McDonald-DUE9850423, Gaede-DUE9750847) and on a Journal of Chemical Education (JCE) article (Davis-JCE, 99). Most experiments have been adapted from JCE or NSF-DUE funded projects and implemented into our curriculum. For example, in General Chemistry, students are investigating electronegativity as well as the heavy atom effect by obtaining C-13 NMR spectra of halogenated methanes (Baer-JCE, 99). In Organic Chemistry, C-13 NMR is being introduced early in the semester (Reeves-JCE, 98), eventually leading to the introduction of H-NMR. Once the basics are established, NMR is then being used for structure determination, to determine optical purity (Viswanathan-JCE, 95), to study Markovnikov verses anti-Markovnikov hydration (Smart-DUE0087655, Nolan-DUE008827, Blankespoor-JCE, 91), and to determine the stereochemistry of hydride reduction (McDonald-DUE9850423). In Instrumental Analysis, students are exploring how different parameters change the appearance of a spectrum (Gaede-DUE9750847) and investigating the nuclear Overhauser effect (Schmedake-JCE, 96). In Physical Chemistry students are performing variable temperature NMR kinetic and thermodynamic studies (McDonald-DUE9850423, Gallaher-JCE, 96). Advance NMR techniques (two-dimensional, heteronuclear, isotopic labeling, etc.) are becoming an integral part of Biochemistry, Advanced Organic Chemistry, Advanced Inorganic Chemistry and student/faculty research.

化学（12）斯通希尔学院正在将高场FT-NMR整合到整个化学课程中，以加强学生保留所学内容、建立课程之间的联系、解释光谱结果和设计实验的能力。该项目正在影响化学，生物化学，生物学，环境研究和计算机工程专业。在整个课程中纳入高场FT-NMR是基于NSF-DUE资助的项目（Nolen-DUE 008827，Smart-DUE 0087655，Wallace-DUE 9952343，McDonald-DUE 9850423，Gaede-DUE 9750847）和化学教育杂志（JCE）文章（Davis-JCE，99）。大多数实验都改编自JCE或NSF-DUE资助的项目，并在我们的课程中实施。例如，在普通化学中，学生通过获得卤代甲烷的C-13 NMR光谱来研究电负性以及重原子效应（Baer-JCE，99）。在有机化学中，C-13 NMR在学期初引入（Reeves-JCE，98），最终导致H-NMR的引入。一旦建立了基础，NMR就用于结构测定，以测定光学纯度（Viswanathan-JCE，95），研究Markovnikov与反Markovnikov水合作用（Smart-DUE 0087655，Nolan-DUE 008827，Blankespoor-JCE，91），并测定氢化物还原的立体化学（McDonald-DUE 9850423）。在仪器分析中，学生将探索不同参数如何改变光谱的外观（Gaede-DUE 9750847），并研究核Overhauser效应（Schmedake-JCE，96）。在物理化学中，学生正在进行变温NMR动力学和热力学研究（McDonald-DUE 9850423，Gallaher-JCE，96）。先进的核磁共振技术（二维、异构、同位素标记等）正在成为生物化学，高级有机化学，高级无机化学和学生/教师研究的组成部分。