Integrating Hands-On Access to High Field NMR Across the Undergraduate Chemistry Curriculum

化学(12)斯通希尔学院正在整个化学课程中整合高场FT-核磁共振，以加强学生记住所学知识、在课程之间建立联系、解释光谱结果和设计实验的能力。这个项目正在影响化学、生物化学、生物学、环境研究和计算机工程专业的学生。在整个课程中纳入高场FT-核磁共振是基于NSF到期的资助项目(NOLEN-DUE008827，SMART-DUE0087655，Wallace-DUE9952343，McDonald-DUE9850423，Gaeed-DUE9750847)和《化学教育杂志》(JCE)的一篇文章(Davis-JCE，99)。大多数实验都是从JCE或NSF资助的项目中改编而来，并被实施到我们的课程中。例如，在普通化学中，学生通过获得卤代甲烷的C-13核磁共振谱来研究电负性和重原子效应(Baer-JCE，99)。在有机化学中，C-13核磁共振是在本学期的早期引入的(里维斯-JCE，98)，最终导致了H-核磁共振的引入。一旦基本建立，核磁共振然后被用于结构确定，以确定光学纯度(Viswanathan-JCE，95)，研究Markovnikov与反Markovnikov水合(Smart-DUE0087655，Nolan-DUE008827，Blankespor-JCE，91)，并确定氢化物还原的立体化学(McDonald-DUE9850423)。在仪器分析中，学生们正在探索不同的参数如何改变光谱的外观(Gaed-DUE9750847)，并研究核欧豪泽效应(Schmedake-JCE，96)。在物理化学中，学生正在进行变温核磁共振动力学和热力学研究(McDonald-DUE9850423，Gallaher-JCE，96)。先进的核磁共振技术(二维、异核、同位素标记等)正在成为生物化学、高级有机化学、高级无机化学和学生/教师研究的重要组成部分。

Chemistry (12)Stonehill College is integrating high field FT-NMR across the entire chemistry curriculum in order to strengthen the ability of students to retain what they learn, draw connections between courses, interpret spectroscopic results, and design experiments. This project is impacting chemistry, biochemistry, biology, environmental studies, and computer engineering majors. The incorporation of high field FT-NMR across the entire curriculum is based on NSF-DUE funded projects (Nolen-DUE008827, Smart-DUE0087655, Wallace-DUE9952343, McDonald-DUE9850423, Gaede-DUE9750847) and on a Journal of Chemical Education (JCE) article (Davis-JCE, 99). Most experiments have been adapted from JCE or NSF-DUE funded projects and implemented into our curriculum. For example, in General Chemistry, students are investigating electronegativity as well as the heavy atom effect by obtaining C-13 NMR spectra of halogenated methanes (Baer-JCE, 99). In Organic Chemistry, C-13 NMR is being introduced early in the semester (Reeves-JCE, 98), eventually leading to the introduction of H-NMR. Once the basics are established, NMR is then being used for structure determination, to determine optical purity (Viswanathan-JCE, 95), to study Markovnikov verses anti-Markovnikov hydration (Smart-DUE0087655, Nolan-DUE008827, Blankespoor-JCE, 91), and to determine the stereochemistry of hydride reduction (McDonald-DUE9850423). In Instrumental Analysis, students are exploring how different parameters change the appearance of a spectrum (Gaede-DUE9750847) and investigating the nuclear Overhauser effect (Schmedake-JCE, 96). In Physical Chemistry students are performing variable temperature NMR kinetic and thermodynamic studies (McDonald-DUE9850423, Gallaher-JCE, 96). Advance NMR techniques (two-dimensional, heteronuclear, isotopic labeling, etc.) are becoming an integral part of Biochemistry, Advanced Organic Chemistry, Advanced Inorganic Chemistry and student/faculty research.