Mechanstic and Exploratory Organic Photochemistry

这项工作的重点是两个方面：1)发展新的光化学反应和2)对有机光反应机制的理论和实验理解。在合成有机光化学方面，将探索几种新的光化学重排反应以及一些新的杂环光化学反应，这些反应将导致光化学合成β -内酰胺。在晶格内发生的主客体或固态光反应将继续被探索。预测和模拟有机光化学过程的三种不同的理论方法也将被研究。有了这个奖项，有机和大分子化学项目支持了威斯康星大学化学系Howard E. Zimmerman博士的研究。Zimmerman博士将探索新的有机光化学反应，并从理论上预测和模拟现有光化学反应的结果。所研究的光化学反应将作为新的合成有机程序的基础，因此在制备抗生素（特别是要研究的杂环光化学）和其他药物方面具有潜在的应用。在本课程中接受教育的学生将在理论和实验有机化学和制备光化学方面得到广泛的培训，并获得制药行业所需的技能。

The emphasis of this work is two fold: 1) development of new photochemical reactions and 2) the theoretical as well as experimental understanding of mechanisms of organic photoreactions. On the synthetic organic photochemistry side, several new photochemical rearrangement reactions will be explored as well as some new heterocyclic photochemistry that should lead to a photochemical beta-lactam synthesis. Host-guest or solid state photoreactions which occur within a crystal lattice will continue to be explored. Three different theoretical methods for predicting and modelling organic photochemical processes will also be studied. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Howard E. Zimmerman of the Department of Chemistry at the University of Wisconsin. Dr. Zimmerman will explore new organic photochemical reactions and work to theoretically predict and model the outcomes of existing photochemical reactions. The photochemical reactions studied will serve as the foundation for new synthetic organic procedures and thus have potential applications for the preparation of antibiotics (particularly the heterocyclic photochemistry to be studied) and other pharmaceuticals. Students educated during the course of this work will be broadly trained in theoretical and experimental organic chemistry and preparative photochemistry and gain skills needed by the pharmaceutical industry.