Mechanstic and Exploratory Organic Photochemistry

这项工作的重点有两个方面：1)新的光化学反应的发展；2)对有机光反应机理的理论和实验理解。在合成有机光化学方面，将探索几个新的光化学重排反应以及一些新的杂环光化学，这些反应将导致β-内酰胺的光化学合成。将继续探索发生在晶格内的主-客体或固态光反应。还将研究用于预测和模拟有机光化学过程的三种不同的理论方法。通过这个奖项，有机和高分子化学项目支持威斯康星大学化学系的Howard E.Zimmerman博士的研究。齐默尔曼博士将探索新的有机光化学反应，并致力于从理论上预测现有光化学反应的结果并对其进行建模。所研究的光化学反应将作为新的合成有机程序的基础，因此在制备抗生素(特别是将要研究的杂环光化学)和其他药物方面具有潜在的应用前景。在这项工作的过程中教育的学生将在理论和实验有机化学和制备光化学方面进行广泛的培训，并获得制药行业所需的技能。

The emphasis of this work is two fold: 1) development of new photochemical reactions and 2) the theoretical as well as experimental understanding of mechanisms of organic photoreactions. On the synthetic organic photochemistry side, several new photochemical rearrangement reactions will be explored as well as some new heterocyclic photochemistry that should lead to a photochemical beta-lactam synthesis. Host-guest or solid state photoreactions which occur within a crystal lattice will continue to be explored. Three different theoretical methods for predicting and modelling organic photochemical processes will also be studied. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Howard E. Zimmerman of the Department of Chemistry at the University of Wisconsin. Dr. Zimmerman will explore new organic photochemical reactions and work to theoretically predict and model the outcomes of existing photochemical reactions. The photochemical reactions studied will serve as the foundation for new synthetic organic procedures and thus have potential applications for the preparation of antibiotics (particularly the heterocyclic photochemistry to be studied) and other pharmaceuticals. Students educated during the course of this work will be broadly trained in theoretical and experimental organic chemistry and preparative photochemistry and gain skills needed by the pharmaceutical industry.