Mechanstic and Exploratory Organic Photochemistry

机械和探索性有机光化学

• 批准号: 0131322
• 负责人: Howard Zimmerman
• 金额: $ 45.4万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0131322&HistoricalAwards=false
• 关键词: Mechanstic; Exploratory; Organic; Photochemistry

The emphasis of this work is two fold: 1) development of new photochemical reactions and 2) the theoretical as well as experimental understanding of mechanisms of organic photoreactions. On the synthetic organic photochemistry side, several new photochemical rearrangement reactions will be explored as well as some new heterocyclic photochemistry that should lead to a photochemical beta-lactam synthesis. Host-guest or solid state photoreactions which occur within a crystal lattice will continue to be explored. Three different theoretical methods for predicting and modelling organic photochemical processes will also be studied. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Howard E. Zimmerman of the Department of Chemistry at the University of Wisconsin. Dr. Zimmerman will explore new organic photochemical reactions and work to theoretically predict and model the outcomes of existing photochemical reactions. The photochemical reactions studied will serve as the foundation for new synthetic organic procedures and thus have potential applications for the preparation of antibiotics (particularly the heterocyclic photochemistry to be studied) and other pharmaceuticals. Students educated during the course of this work will be broadly trained in theoretical and experimental organic chemistry and preparative photochemistry and gain skills needed by the pharmaceutical industry.

本工作的重点是两个方面：1）新的光化学反应的发展和2）理论和实验的有机光反应的机制的理解。 在合成有机光化学方面，将探索几种新的光化学重排反应，以及一些新的杂环光化学，应该导致光化学β-内酰胺合成。 在晶格内发生的主-客体或固态光反应将继续被探索。 三种不同的理论方法预测和模拟有机光化学过程也将进行研究。 有了这个奖项，有机和高分子化学计划是支持博士霍华德E。威斯康星州大学化学系的齐默尔曼说。 齐默尔曼博士将探索新的有机光化学反应，并从理论上预测和模拟现有光化学反应的结果。 所研究的光化学反应将作为新的有机合成程序的基础，因此在制备抗生素（特别是待研究的杂环光化学）和其他药物方面具有潜在的应用。 在这项工作的过程中接受教育的学生将在理论和实验有机化学和制备光化学方面得到广泛的培训，并获得制药行业所需的技能。