CAREER: Roles of hippocampal/neostriatal systems in multiple forms of memory

职业：海马/新纹状体系统在多种记忆形式中的作用

• 批准号: 0133734
• 负责人: Paul Colombo
• 金额: $ 56.01万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0133734&HistoricalAwards=false
• 关键词: CAREER; Roles; hippocampal; neostriatal; systems

LAY ABSTRACT Proposal # : IBN-0133734 PI Name: Paul ColomboThis career development plan integrates teaching, mentoring, and research goals within the context of Tulane University's mission to promote neuroscience research and education. The educational goals include development of lecture and laboratory curricula for the new undergraduate neuroscience major, and recruitment of undergraduate students from groups traditionally underrepresented in the neurosciences to participate in research training internships during the summer months. The broad research goal of this project is to systematically define relationships between two brain regions known to support different types of memory among mammalian species: the neostriatum and the hippocampal formation. Although the roles of these two systems have been dissociated experimentally, the extent to which they function independently, cooperatively, competitively, or in temporal sequence is not known currently. Moreover, the time courses and cellular mechanisms of memory formation supported by these two systems are not well understood. Memory formation is accompanied by brain region-specific changes among neurons involved in information processing. Hypotheses that these changes are memory- and brain region-specific will be tested: neostriatal activation supports response, nonspatial, and procedural memory, whereas hippocampal activation supports place, spatial, and declarative memory. The current proposal employs two primary research strategies. The first strategy is to use behavioral manipulations to induce learning-related changes in cellular mechanisms of memory formation and to quantify those changes within the neostriatum and hippocampal formation. The second research strategy is to test the effects of highly selective protein inhibition on acquisition and retention of neostriatal- and hippocampal-dependent memory. By combining these research strategies, relationships between the hippocampal formation and neostriatum will be elucidated during multiple types of memory formation at the behavioral, brain systems, and neuronal levels of analyses.In addition to the research goals of this proposal, two additional goals both involve integration of research, teaching, and mentoring. The first of these goals is to increase opportunities for neuroscience education and research experiences for students from groups traditionally underrepresented in the neurosciences by mentoring students in the laboratory during the summer, and by outreach visits to colleges in the area. The second goal is to continue to develop the undergraduate major in Neuroscience at Tulane University.

LAY ABSTRACT提案编号：IBN-0133734 PI姓名：Paul Colombo该职业发展计划将教学，指导和研究目标整合在杜兰大学的使命范围内，以促进神经科学研究和教育。 教育目标包括为新的本科神经科学专业开发讲座和实验室课程，以及从传统上在神经科学中代表性不足的群体中招募本科生，在夏季参加研究培训实习。该项目的广泛研究目标是系统地定义已知支持哺乳动物物种中不同类型记忆的两个大脑区域之间的关系：新纹状体和海马结构。 虽然这两个系统的作用已被分离实验，在何种程度上，他们的功能独立，合作，竞争，或在时间序列目前还不知道。 此外，由这两个系统支持的记忆形成的时间过程和细胞机制还没有得到很好的理解。 记忆的形成伴随着参与信息处理的神经元之间的大脑区域特异性变化。 假设这些变化是记忆和大脑区域特异性将进行测试：新纹状体激活支持响应，非空间和程序性记忆，而海马激活支持位置，空间和陈述性记忆。 目前的建议采用了两个主要的研究战略。 第一种策略是使用行为操作来诱导记忆形成的细胞机制中与学习相关的变化，并量化新纹状体和海马结构中的这些变化。第二个研究策略是测试高选择性蛋白质抑制对新纹状体和海马依赖性记忆的获得和保持的影响。 通过结合这些研究策略，海马结构和新纹状体之间的关系将阐明在多种类型的记忆形成过程中的行为，脑系统和神经元水平的analysis. Although本提案的研究目标，两个额外的目标都涉及研究，教学和指导的整合。 这些目标中的第一个是增加神经科学教育和研究经验的机会，从传统上在神经科学中代表性不足的群体的学生在夏季在实验室指导学生，并通过外展访问该地区的大学。 第二个目标是继续发展杜兰大学的神经科学本科专业。