Molecular Genetic Studies of Bdelloid Rotifers

蛭形轮虫的分子遗传学研究

• 批准号: 0135217
• 负责人: Matthew Meselson
• 金额: $ 58.55万
• 依托单位: Marine Biological Laboratory
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0135217&HistoricalAwards=false
• 关键词: Molecular; Genetic; Studies; Bdelloid; Rotifers

This project will investigate genome structure and its evolution in rotifers of the Class Bdelloidea, an extraordinary group of invertebrate animals that appears to have evolved for tens of millions of years without sexual reproduction. In particular, the project will: (i) initiate the basic characterization of bdelloid genomes; (ii) examine specific genes for the occurrence of genetic recombination within a bdelloid genome; (iii) determine the genomic consequences of long-term ameiotic evolution; and (iv) possibly discover novel features of bdelloid genomes that might provide insight into what has allowed bdelloid rotifers to evolve successfully without genetic exchange, and, correspondingly, what causes most other populations of animals and plants that become asexual to suffer early extinction - a long-standing fundamental problem in biology.

该项目将研究蛭形目轮虫的基因组结构及其进化，蛭形目轮虫是一组非凡的无脊椎动物，似乎已经进化了数千万年，没有有性生殖。 特别是，该项目将：㈠开始蛭形动物基因组的基本特征鉴定; ㈡检查蛭形动物基因组内发生遗传重组的特定基因; ㈢确定长期无减数分裂进化的基因组后果;以及（iv）可能发现蛭形轮虫基因组的新特征，这些特征可能会让我们深入了解是什么让蛭形轮虫在没有遗传交换的情况下成功进化，以及，相应地，是什么原因导致大多数其他无性繁殖的动植物种群过早灭绝--这是生物学上一个长期存在的基本问题。