Molecular, genetic and physiological studies of calcium-activated chloride channels

钙激活氯离子通道的分子、遗传和生理学研究

• 批准号: 10208116
• 负责人: LILY Y JAN
• 金额: $ 16.15万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10208116
• 关键词: Action Potentials; Address; Affect; Ambystoma; Anions; Automobile Driving; Award; Binding Sites; Calcium; Chemosensitization; Chloride Channels; Collaborations; Cryoelectron Microscopy; Cytosol; Dependence; Detergents; Development; Divalent Cations; Experimental Designs; Feedback; Future; Hippocampus (Brain); Inferior; Intervention; Ions; Kinetics; Lead; Lipid Bilayers; Membrane; Membrane Potentials; Molecular; Molecular Conformation; Molecular Genetics; Motor; Mus; Mutagenesis; N-Methyl-D-Aspartate Receptors; Neurons; Oocytes; Parents; Pathway interactions; Physiological; Play; Property; Regulation; Resolution; Role; Source; Structure; Synaptic Potentials; Therapeutic; Transcript; Transmembrane Domain; Work; Xenopus oocyte; base; biophysical analysis; biophysical techniques; constriction; experience; expression cloning; extracellular; fascinate; insight; nanodisk; neurotransmission; novel; particle; prevent; reconstitution; voltage

Project Summary/Abstract Not applicable. No change from Parent Award.

项目总结/文摘

项目成果

Multi-scale spatial heterogeneity enhances particle clearance in airway ciliary arrays.

• DOI: 10.1038/s41567-020-0923-8
• 发表时间: 2020-09
• 期刊: Nature physics
• 影响因子: 19.6

Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia.

• DOI: 10.1038/nm.3543
• 发表时间: 2014-06
• 期刊: Nature medicine
• 影响因子: 82.9

Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae.

• DOI: 10.7554/elife.03293
• 发表时间: 2014-10-30
• 期刊: eLife
• 影响因子: 7.7
• 作者: Zhang W;Yan Z;Li B;Jan LY;Jan YN
• 通讯作者: Jan YN

Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.

• DOI: 10.1126/scitranslmed.aac5608
• 发表时间: 2015-11-25
• 期刊: Science translational medicine
• 影响因子: 17.1
• 作者: Headland SE;Jones HR;Norling LV;Kim A;Souza PR;Corsiero E;Gil CD;Nerviani A;Dell'Accio F;Pitzalis C;Oliani SM;Jan LY;Perretti M
• 通讯作者: Perretti M

Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury.

• DOI: 10.1016/j.celrep.2015.09.080
• 发表时间: 2015-11-10
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Petitjean H;Pawlowski SA;Fraine SL;Sharif B;Hamad D;Fatima T;Berg J;Brown CM;Jan LY;Ribeiro-da-Silva A;Braz JM;Basbaum AI;Sharif-Naeini R
• 通讯作者: Sharif-Naeini R