Real-Time Animal Telemetry

实时动物遥测

• 批准号: 0138011
• 负责人: Paul Garris
• 金额: $ 51.99万
• 依托单位: Board of Trustees of Illinois State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0138011&HistoricalAwards=false
• 关键词: Real; Time; Animal; Telemetry

A grant has been awarded to Dr. Paul A. Garris at Illinois State Universityto develop a new instrument for wireless monitoring of neural activity inthe brain of awake, unrestrained animals. The new instrument, calledreal-time animal telemetry (RAT), will combine two powerful technologies;microsensors for spatially and temporally resolved measurements, and digitaltelemetry for remote data transmission and system control with high speedand high fidelity. The primary advantage of RAT will be sub-secondcharacterization of brain function with minimal perturbation of behavior. The proposed RAT instrument holds great promise for advancing the study of brain-behavior relationships.RAT will be a modular and multifunctional instrument, a design that advancesdevelopment and affords flexibility to its application. Several types ofmeasurement techniques will be incorporated into RAT: Voltammetry which monitors the chemistry of the brain and electrophysiology whichmeasures brain bioelectrical activity. Combined, the techniques assess therelease of a neurotransmitter and its postsynaptic effect to obtain a moreintegrative view of brain function. Although great strides have recently been made applying real-time voltammetry and electrophysiology to awake animals, the connection between sensor and recording equipment is made by a cable tether. Unfortunately, the hard connection affects behavior and hinders or even prevents investigation of important paradigms such as those involving social interactions and complex environments. To overcome this problem, the new instrument will use a wireless link. Moreover, because real-time voltammetric and electrophysiological measurements are very susceptible to transmission artifacts, RAT will use high fidelity digital telemetry.Ultimately, RAT should be commercially viable instrumentation in the support ofbiological research. The incorporation of well-established techniques willmake the proposed RAT instrument attractive to large number of users workingin the neuroscience fields. With further development, there is enormouspotential for RAT to support other existing real-time microsensors. RAT canalso evolve to accommodate sensor technologies that emerge in the future.

伊利诺伊州立大学的保罗·A·加里斯博士获得了一项拨款，用于开发一种新的仪器，用于无线监测清醒的、无拘无束的动物的大脑神经活动。这台新仪器被称为实时动物遥测(RAT)，它将结合两项强大的技术：用于空间和时间分辨率测量的微型传感器，以及用于高速高保真远程数据传输和系统控制的数字遥测。大鼠的主要优势将是在行为干扰最小的情况下对大脑功能进行亚秒级表征。拟议中的RAT仪器为推进脑-行为关系的研究带来了巨大的希望。RAT将成为一种模块化和多功能的仪器，这种设计促进了开发，并为其应用提供了灵活性。几种类型的测量技术将被纳入老鼠体内：伏安法，它监测大脑的化学成分；电生理学，它测量大脑的生物电活动。这些技术结合在一起，评估神经递质的释放及其突触后效应，以获得对大脑功能的更全面的看法。虽然最近在应用实时伏安法和电生理学来唤醒动物方面取得了很大进展，但传感器和记录设备之间的连接是通过电缆系绳实现的。不幸的是，硬连接影响了行为，阻碍甚至阻止了对重要范式的研究，例如涉及社会互动和复杂环境的范式。为了克服这个问题，新仪器将使用无线连接。此外，由于实时伏安和电生理测量非常容易受到传输伪影的影响，大鼠将使用高保真数字遥测。最终，大鼠应该是商业上可行的支持生物学研究的仪器。结合成熟的技术将使拟议的大鼠仪器对神经科学领域的大量用户具有吸引力。随着进一步的发展，RAT对其他已有的实时微传感器的支持具有巨大的潜力。RAT也可以进化以适应未来出现的传感器技术。