ADVANCE Fellow: The Role of Electrostatics in Nucleic Acid Structure and Function

这个高级研究员奖，通过化学和物理学部，将支持佛罗里达州立大学分子生物物理研究所的Marcia O. Fenley的研究。该项目将使用理论和计算方法来阐明静电对核酸结构和功能的作用。具体来说，三链核酸模型结构的离子气氛和静电势将使用数值反离子冷凝和泊松-玻尔兹曼方法进行研究。这些计算可以阐明各种离子对核酸结构、构象变化和相变的作用。该奖项由美国国家科学基金会ADVANCE计划资助。ADVANCE计划的总体任务是通过增加女性在学术科学和工程职业中的代表性和进步来增加女性在科学和工程劳动力中的参与度。

This ADVANCE Fellows award, through the Divisions of Chemistry and Physics, will support the research of Marcia O. Fenley in the Institute of Molecular Biophysics at Florida State University. The project will use theoretical and computational approaches to elucidate the role of electrostatics on the structure and function of nucleic acids. Specifically, the ion atmosphere and electrostatic potential of model structures of triple-stranded nucleic acids will be examined using numerical counterion condensation and Poisson-Boltzmann methods. These calculations may elucidate the role of various ions on nucleic acid structure, conformation changes and phase transitions. This award is supported through the NSF ADVANCE Program. The overall mission of the ADVANCE Program is to increase the participation of women in the scientific and engineering workforce through the increased representation and advancement of women in academic science and engineering careers.