US-India Cooperative Research: Enzyme-Inorganic Materials: Peroxidase Behavior at Selected Interfaces

0138401 Kumar描述：该奖项是美国和印度在生物化学领域的合作研究，题为酶-无机材料：选定界面处的过氧化物酶行为。 研究人员将测试固体表面扰动酶结构的假设，以及扰动的程度取决于固体和酶之间相互作用的强度。 本研究中解决的关键问题是重要的酶结合材料的合理设计。 这类先进材料可应用于生物催化、生物传感器、植入物和人造器官。 适用范围：这启动了康涅狄格大学美国PI Challa V. Kumar与印度理工学院（IIT）孟买C. P. Rao和Osamania大学V. Jagannadham之间的三方合作。 拟定研究是美国PI研究兴趣的逻辑延伸，与合作者的兴趣重叠。 IIT集团带来了他们在配体/金属络合物的设计，合成和表征方面的专业知识，而IIT集团则带来了其在反应动力学和机理研究方面的高水平专业知识。 它将加强所有三个机构的研究和教学活动。 该项目由印度科学技术部（DST）在NSF/DST联合计划下支持。

0138401KumarDescription: This award is for US-India collaborative research in biochemistry entitled Enzyme-Inorganic Materials: Peroxidase Behavior at Selected Interfaces. The investigators will test the hypothesis that solid surfaces perturb enzyme structure, and that the extent of perturbation depends on the strength of interaction between the solid and the enzyme. The key issues addressed in this research are important for the rational design of materials for enzyme binding. Advanced materials of this type have applications in biocatalysis, biosensors, implants, and artificial organs. Scope: This initiates a three-way collaboration between US PI Challa V. Kumar of the University of Connecticut and C.P. Rao, Indian Institute of Technology (IIT) Mumbai and V. Jagannadham, Osamania University (OU). The proposed studies are logical extensions of the research interests of the US PI and overlap with the collaborators interests. The IIT group brings to the collaboration their expertise in design, synthesis, and chacterization of ligands/metal complexes, while the OU group brings its high level expertise in reaction kinetics and mechanistic studies. It will enhance research and teaching activities at all three institutions. The project is supported by the Indian Department of Science and Technology(DST) under the NSF/DST joint program.