US-India Cooperative Research: Enzyme-Inorganic Materials: Peroxidase Behavior at Selected Interfaces

该奖项授予美印在生物化学领域的合作研究，题为“酶-无机材料：过氧化物酶在选定界面上的行为”。研究人员将测试固体表面扰乱酶结构的假设，而扰动的程度取决于固体和酶之间相互作用的强度。本研究解决的关键问题对酶结合材料的合理设计具有重要意义。这类先进材料在生物催化、生物传感器、植入物和人造器官等方面都有应用。范围：这开启了康涅狄格大学的PI Challa V. Kumar和印度理工学院孟买分校的C.P. Rao以及奥萨马尼亚大学的V. Jagannadham之间的三方合作。建议的研究是美国PI研究兴趣的逻辑延伸，并与合作者的兴趣重叠。IIT团队带来了他们在配体/金属配合物的设计、合成和表征方面的专业知识，而OU团队则带来了其在反应动力学和机理研究方面的高水平专业知识。它将加强这三所大学的研究和教学活动。该项目由印度科学技术部（DST）根据国家科学基金会/DST联合计划提供支持。

0138401KumarDescription: This award is for US-India collaborative research in biochemistry entitled Enzyme-Inorganic Materials: Peroxidase Behavior at Selected Interfaces. The investigators will test the hypothesis that solid surfaces perturb enzyme structure, and that the extent of perturbation depends on the strength of interaction between the solid and the enzyme. The key issues addressed in this research are important for the rational design of materials for enzyme binding. Advanced materials of this type have applications in biocatalysis, biosensors, implants, and artificial organs. Scope: This initiates a three-way collaboration between US PI Challa V. Kumar of the University of Connecticut and C.P. Rao, Indian Institute of Technology (IIT) Mumbai and V. Jagannadham, Osamania University (OU). The proposed studies are logical extensions of the research interests of the US PI and overlap with the collaborators interests. The IIT group brings to the collaboration their expertise in design, synthesis, and chacterization of ligands/metal complexes, while the OU group brings its high level expertise in reaction kinetics and mechanistic studies. It will enhance research and teaching activities at all three institutions. The project is supported by the Indian Department of Science and Technology(DST) under the NSF/DST joint program.