US-India Cooperative Research: Enzyme-Inorganic Materials: Peroxidase Behavior at Selected Interfaces

0138401KumarDescription：这个奖项是为了表彰美国和印度在生物化学方面的合作研究，题目是酶-无机材料：选定界面的过氧化物酶行为。研究人员将验证这样一种假设，即固体表面会扰乱酶的结构，扰动的程度取决于固体和酶之间相互作用的强度。本研究所涉及的关键问题对于合理设计酶结合材料具有重要意义。这类先进材料在生物催化、生物传感器、植入物和人造器官方面有应用。范围：这启动了美国康涅狄格大学的Pi Challa V.Kumar与印度理工学院(IIT)孟买的C.P.Rao和奥萨马尼亚大学(OU)的V.Jagannadham之间的三方合作。拟议的研究是美国国际和平研究所研究兴趣的合乎逻辑的延伸，并与合作者的兴趣重叠。IIT小组带来了他们在配体/金属络合物设计、合成和表征方面的专业知识，而OU小组则带来了其在反应动力学和机理研究方面的高水平专业知识。它将加强所有三所院校的研究和教学活动。该项目由印度科技部(DST)在NSF/DST联合计划下提供支持。

0138401KumarDescription: This award is for US-India collaborative research in biochemistry entitled Enzyme-Inorganic Materials: Peroxidase Behavior at Selected Interfaces. The investigators will test the hypothesis that solid surfaces perturb enzyme structure, and that the extent of perturbation depends on the strength of interaction between the solid and the enzyme. The key issues addressed in this research are important for the rational design of materials for enzyme binding. Advanced materials of this type have applications in biocatalysis, biosensors, implants, and artificial organs. Scope: This initiates a three-way collaboration between US PI Challa V. Kumar of the University of Connecticut and C.P. Rao, Indian Institute of Technology (IIT) Mumbai and V. Jagannadham, Osamania University (OU). The proposed studies are logical extensions of the research interests of the US PI and overlap with the collaborators interests. The IIT group brings to the collaboration their expertise in design, synthesis, and chacterization of ligands/metal complexes, while the OU group brings its high level expertise in reaction kinetics and mechanistic studies. It will enhance research and teaching activities at all three institutions. The project is supported by the Indian Department of Science and Technology(DST) under the NSF/DST joint program.