Integrated System for Ensemble Recording of Neuronal Activity in the Mammalian Brain

哺乳动物大脑神经元活动整体记录集成系统

• 批准号: 0138848
• 负责人: Charles Gray
• 金额: $ 83.71万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0138848&HistoricalAwards=false
• 关键词: Integrated; System; Ensemble; Recording; Neuronal

This award provides funding for the development of a multichannel recording device that can be used to monitor activity of multiple individual neurons in the mammalian brain. Although it is now accepted by most neuroscientists that most brain functions reflect the concerted efforts of many neurons, direct demonstrations have been hampered by the limitations of currently available technology for single-cell recording from the brain, including the lack of automation in electrode placement, a relatively low number of electrodes that can be used simultaneously, and a relatively high cost. The device to be developed should significantly improve on the technical limitations of existing hardware, while not increasing the cost of the equipment needed . Important features include a low cost manipulator system that can position up to 64 electrodes independently of each other, a feedback control system that will couple positioning of the electrodes to the signals detected by the electrodes, and an implant device that allows implanted electrodes to be left in place for long-term recording.

该奖项为开发多通道记录设备提供资金，该设备可用于监测哺乳动物大脑中多个单个神经元的活动。 虽然现在大多数神经科学家都认为，大多数大脑功能反映了许多神经元的协同努力，但直接演示受到目前可用的大脑单细胞记录技术的限制，包括缺乏电极放置的自动化，可以同时使用的电极数量相对较少，以及相对较高的成本。 拟开发的装置应大大改善现有硬件的技术限制，同时不增加所需设备的成本。 重要的特征包括一个低成本的操纵器系统，它可以相互独立地定位多达64个电极，一个反馈控制系统，它将电极的定位与电极检测到的信号相耦合，以及一个植入装置，它允许植入的电极留在原位进行长期记录。