Development of a Chronically Implantable Retinal Prothesis

长期植入性视网膜假体的开发

• 批准号: 0201861
• 负责人: John Wyatt
• 金额: $ 27万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-10-01 至 2005-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0201861&HistoricalAwards=false
• 关键词: Development; Chronically; Implantable; Retinal; Prothesis

0201861WyattThis research project is to develop and test a prototype prosthetic device for restoring some useful vision to blind humans who have retinal disease. The investigators will apply their microfabrication and surgical expertise to the development of a prosthesis, which can be successfully implanted for a period of months or years without affecting the delicate surrounding tissue in the eye. The wireless, inflatable prosthesis is to receive its power from outside the body by radio frequency transmission. A new form of low-power circuitry is to be developed for the implant to reduce heating effects in the eye. This thin silicon circuit, integral to the implant, will transmit simple patterns to an array of stimulating electrodes located on flexible, spider-like 'arms' which are to be folded-up for insertion through a small incision in the eye. Once inside the eye they can then be inflated for attachment to a larger area of retina. A parallel effort will develop encapsulation technology to protect these implants from bodily fluids. This project is jointly funded by the National Science Foundation (NSF) and the Department of Veterans Affairs (DVA) under the terms of a Letter of Agreement of April 19, 2002. The research will be conducted at the Massachusetts Institute of Technology (MIT) and the Cornell University Nanofabrication Facility. Testing of the various versions of the prototype implant is to be done at MIT and the DVA Center for Innovative Visual Rehabilitation in the DVA Medical Center, Boston, Massachusetts.

0201861Wyatt 该研究项目旨在开发和测试原型假肢装置，用于为患有视网膜疾病的盲人恢复一些有用的视力。研究人员将运用他们的微加工和外科专业知识来开发假体，这种假体可以成功植入数月或数年，而不会影响眼睛周围脆弱的组织。无线充气假肢通过射频传输从体外接收能量。将为植入物开发一种新型低功率电路，以减少眼睛中的热效应。这种薄硅电路是植入物的一部分，它将简单的模式传输到位于灵活的蜘蛛状“臂”上的刺激电极阵列，这些电极将折叠起来通过眼睛的小切口插入。一旦进入眼睛，它们就可以膨胀以附着到更大的视网膜区域。与此同时，我们还将开发封装技术，以保护这些植入物免受体液的影响。该项目由美国国家科学基金会 (NSF) 和退伍军人事务部 (DVA) 根据 2002 年 4 月 19 日签署的协议书共同资助。该研究将在麻省理工学院 (MIT) 和康奈尔大学纳米加工设施进行。各种版本原型植入物的测试将在麻省理工学院和马萨诸塞州波士顿 DVA 医疗中心的 DVA 创新视觉康复中心进行。