Neural bases for lateralised attentional neglect within chronically depressed populations

长期抑郁人群中偏侧注意力忽视的神经基础

• 批准号: 2743905
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2743905
• 关键词: Neural; bases; lateralised; attentional; neglect

The proposed research aims to investigate the neural underpinnings of the correlation between lateralised attentionaldisruption and anhedonia, in individuals living with a chronic depressive illness. This shall be achieved using aconjunction of neuropsychological tests of visuospatial attention and fMRI methodology. Project objectives: (i) Seek toreplicate previously identified lateralised attentional biases within a chronically depressed population, within visualmodalities, whilst considering levels of anhedonic symptomology. (ii) Investigate potential differences in the neuralnetworks mediating stimulus-driven attention between a chronically depressed population and healthy controls. (iii) Gaininsight into patterns of responding for left-handed individuals, in both clinical and control populations. Component 1 In aninitial set of experiments, participants shall complete a variation of the Posner (1980) cueing task. Reaction time andaccuracy data shall be collected. Component 2 An event-related functional magnetic resonance imaging (fMRI)component, whereby the Posner (1980) variation shall be administered to participants whilst in the scanner. Reactiontime and accuracy data shall be collected, in addition to the acquisition of anatomical and functional fMRI data. BeckDepression and Waterloo handedness inventories shall be administered, to account for episode severity andhandedness. Further scores shall be obtained for levels of anhedonia.

这项拟议的研究旨在调查患有慢性抑郁症的个人的偏侧注意力中断和快感缺失之间相关性的神经基础。这应结合视觉空间注意的神经心理学测试和功能磁共振成像方法学来实现。项目目标：(I)在考虑非享乐症状水平的同时，寻求在慢性抑郁症人群中复制先前发现的侧向注意偏差。(Ii)调查慢性抑郁症人群和健康对照组之间调节刺激驱动注意力的神经网络的潜在差异。(3)深入了解左撇子在临床和对照人群中的反应模式。在最初的一系列实验中，参与者需要完成Posner(1980)提示任务的一个变体。应收集反应时间和准确度数据。第2部分：事件相关功能磁共振成像(FMRI)部分，其中波斯纳(1980)变异应在扫描仪中对参与者实施。除了获取解剖和功能fMRI数据外，还应收集反应时间和准确性数据。应执行抑郁和滑铁卢惯用手清单，以说明事件的严重性和惯用手。还应获得快感缺乏症水平的进一步评分。