Neural bases for lateralised attentional neglect within chronically depressed populations

这项拟议的研究旨在调查慢性抑郁症患者的侧边注意力中断和快感缺乏之间的神经基础。这将通过结合视觉空间注意力的神经心理学测试和功能磁共振成像方法来实现。项目目标：(i)在长期抑郁人群中，在视觉模式下，同时考虑快感缺乏症状的水平，寻求复制先前确定的侧向注意偏差。（ii）研究慢性抑郁症人群和健康对照组之间介导刺激驱动注意力的神经网络的潜在差异。（iii）深入了解临床和对照人群中左撇子个体的反应模式。在最初的一组实验中，参与者应完成波斯纳（1980）提示任务的一个变体。应收集反应时间和准确度数据。组件2与事件相关的功能性磁共振成像（fMRI）组件，在扫描仪中对参与者进行波斯纳（1980）变异。除了获取解剖和功能fMRI数据外，还需要收集反应时间和精度数据。应进行贝克抑郁和滑铁卢偏手性量表，以说明发作的严重程度和偏手性。快感缺乏的程度需要进一步的评分。

The proposed research aims to investigate the neural underpinnings of the correlation between lateralised attentionaldisruption and anhedonia, in individuals living with a chronic depressive illness. This shall be achieved using aconjunction of neuropsychological tests of visuospatial attention and fMRI methodology. Project objectives: (i) Seek toreplicate previously identified lateralised attentional biases within a chronically depressed population, within visualmodalities, whilst considering levels of anhedonic symptomology. (ii) Investigate potential differences in the neuralnetworks mediating stimulus-driven attention between a chronically depressed population and healthy controls. (iii) Gaininsight into patterns of responding for left-handed individuals, in both clinical and control populations. Component 1 In aninitial set of experiments, participants shall complete a variation of the Posner (1980) cueing task. Reaction time andaccuracy data shall be collected. Component 2 An event-related functional magnetic resonance imaging (fMRI)component, whereby the Posner (1980) variation shall be administered to participants whilst in the scanner. Reactiontime and accuracy data shall be collected, in addition to the acquisition of anatomical and functional fMRI data. BeckDepression and Waterloo handedness inventories shall be administered, to account for episode severity andhandedness. Further scores shall be obtained for levels of anhedonia.