Postdoctoral Research Fellowship in Biological Informatics for FY 2002

2002财年生物信息学博士后研究奖学金

• 批准号: 0204069
• 负责人: Harry Stern
• 金额: $ 10万
• 依托单位: Stern Harry A
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0204069&HistoricalAwards=false
• 关键词: Postdoctoral; Research; Fellowship; Biological; Informatics

This action funds an NSF Postdoctoral Research Fellowship in Biological Informatics for FY2002. The fellowship supports research and training at the postdoctoral level at the intersection of biology and the informational, computational, mathematical, and statistical sciences. The goal of the fellowship is to provide training to a young scientist in preparation for a career in biological informatics in which research and education will be integrated. There is an increasing need for training in biological informatics at all occupational levels, and it is expected that Fellows trained through these fellowships will play important roles in training the future workforce.The research and training plan for this fellowship is entitled "Computer simulation of lipid bilayer permeation." Phospholipid bilayer membranes regulate the transport of molecules into and out of the cell. Though most transport is assisted by channels or membrane proteins, passive transport directly through the bilayer does occur. A molecular-level understanding of membrane permeation can shed light on the blood-brain barrier, the mechanisms of anesthesia, and basic processes such as osmosis and the diffusion of oxygen and carbon dioxide. It may also assist in predicting the bioavailability of orally-administered drugs. The proposed research is the computer simulation of the permeation of small molecules through lipid bilayermembranes using recent algorithms developed for long-time molecular dynamics simulations.

这一行动为2002财政年度的NSF生物信息学博士后研究奖学金提供资金。 该奖学金支持在生物学和信息，计算，数学和统计科学的交叉点博士后水平的研究和培训。该研究金的目标是向一名青年科学家提供培训，为从事研究和教育相结合的生物信息学职业做准备。在所有职业级别上对生物信息学培训的需求日益增加，预计通过这些研究金培训的研究员将在培训未来的劳动力方面发挥重要作用，该研究金的研究和培训计划题为“脂双层渗透的计算机模拟”。“磷脂双层膜调节分子进出细胞的运输。 虽然大多数转运是由通道或膜蛋白辅助的，但也会发生直接通过双分子层的被动转运。 对膜渗透的分子水平的理解可以阐明血脑屏障、麻醉机制以及诸如渗透和氧气和二氧化碳的扩散等基本过程。 它还可以帮助预测口服药物的生物利用度。 拟议的研究是通过脂质双层膜的小分子渗透的计算机模拟，使用最近开发的长时间分子动力学模拟算法。