(Dys)-regulation of the cellular HCV-specific immune response (A06)

(Dys)-细胞 HCV 特异性免疫反应的调节 (A06)

• 批准号: 158180561
• 金额: --
• 依托单位: I. Medizinische Klinik und Poliklinik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/158180561?language=en
• 关键词: Dys; regulation; cellular; HCV; specific

In acute HCV infection CD4 + T cells lose their functionality and the infection chronically in a plurality of patients, under the influence of co-inhibitor molecules. phenotypic and functional examination of intrahepatic and peripheral T cell populations will be at various stages of HCV infection. For this purpose we will also use the antigen MHC class I + II tetramer technology to to perform single-cell transcriptional analysis on different peripheral and intrahepatic antigen-specific T cell populations with different clinical courses. We plan an integrated analysis with other arms (Tregs, Tr1, Th17, NK cells, MAIT cells) of the immune system.

在急性HCV感染中，在共抑制剂分子的影响下，CD4 + T细胞丧失其功能性，并且在许多患者中慢性感染。肝内和外周T细胞群的表型和功能检查将在HCV感染的各个阶段进行。为此，我们还将使用抗原MHC I + II类四聚体技术对不同临床病程的不同外周和肝内抗原特异性T细胞群进行单细胞转录分析。我们计划与免疫系统的其他分支（Tcl3，Tr1，Th17，NK细胞，MAIT细胞）进行综合分析。