Regulatory T cells and TH17 cells in experimental cholangitis (B03)

实验性胆管炎中的调节性 T 细胞和 TH17 细胞 (B03)

• 批准号: 158180913
• 金额: --
• 依托单位: I. Medizinische Klinik und Poliklinik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/158180913?language=en
• 关键词: Regulatory; cells; TH17; experimental; cholangitis

The imbalance of regulatory T cells (Treg) and TH17 cells observed in patients with cholangitis offers the potential for therapeutic intervention. After having established a protocol to significantly expand Treg within the liver in vivo, we will now explore, how these hepatic Treg can be harnessed to become functionally active suppressors in cholangitis. Before IL-17 producing T cells can be targeted for treatment, their functional role in cholangitis needs to be defined. Using our antigen-dependent mouse models, we will investigate in detail the role of IL-17 producing CD8 and CD4 positive T cells in experimental cholangitis.

在胆管炎患者中观察到的调节性T细胞（Treg）和TH 17细胞的不平衡为治疗干预提供了可能。在建立了一个在体内显著扩增肝脏内Treg的方案后，我们现在将探索如何利用这些肝脏Treg成为胆管炎中功能活跃的抑制因子。在产生IL-17的T细胞可以被靶向治疗之前，需要确定它们在胆管炎中的功能作用。使用我们的抗原依赖性小鼠模型，我们将详细研究IL-17产生的CD 8和CD 4阳性T细胞在实验性胆管炎中的作用。