SGER: Inactivation of Biological Warfare Agents by Physical Disinfectants

0210350 Blatchley本研究的目的是调查利用物理消毒剂紫外线（UV）和伽马（g）辐照的炭疽杆菌去污过程的可行性和局限性。 本探索性研究的具体任务包括：（1）建立B行为数据库。炭疽孢子的响应紫外线和g照射，注意到孢子灭活，修复和突变，（2）系统的发展，以量化的剂量输送的去污系统的基础上，物理消毒剂使用蜡状芽孢杆菌作为替代B。炭疽孢子，和（3）在一系列操作条件下连续应用于表面和含水液体的孢子灭活检查，以及剂量测定数据。 B的使用。cereus作为替代物是合理和有用的，因为B.蜡状芽孢杆菌与B几乎没有区别。在生理学和对消毒剂的反应方面，炭疽病是致命的，但对人类基本上没有致病性。 作为B使用有效性的检查。蜡状芽孢杆菌，将用B的Sterne菌株进行有限数量的实验。炭疽菌（该生物体的疫苗株），以验证研究结果。

0210350BlatchleyThe objective of the research is to investigate the feasibility and limitations of Bacillus anthracis decontamination processes which utilize the physical disinfectants ultraviolet (UV) and gamma (g) irradiation. The specific tasks of this exploratory research include: (1) the development of a database of the behavior for B. anthracis spores in response to UV and g irradiation, noting the spore inactivation, repair, and mutation, (2) the development of systems to quantify dose delivery in decontamination systems based on physical disinfectants using Bacillus cereus as a surrogate for B. anthracis spores, and (3) examination of spore inactivation in continuous applications to surfaces and aqueous liquids over a range of operating conditions, together with dosimetric data. The use of B. cereus as a surrogate is logical and useful, since B. cereus is virtually indistinguishable from B. anthracis in terms of physiology and responses to disinfectants, but is essentially non-pathogenic to humans. As a check of the validity of the use of B. cereus, a limited number of experiments will be performed with the Sterne strain of B. anthracis (the vaccine strain of the organism) to verify the results of the research.