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Mechanisms of action of antiestrogens in breast cancer: roles of ubiquitin-like modifications in transcriptional inactivation of Estrogen Receptor alpha.

Mechanisms of action of antiestrogens in breast cancer: roles of ubiquitin-like modifications in transcriptional inactivation of Estrogen Receptor alpha.
抗雌激素在乳腺癌中的作用机制:泛素样修饰在雌激素受体α转录失活中的作用。
批准号:
480045
负责人:
Mader Sylvie N
金额:
$61.3万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2023
资助国家:
加拿大
项目状态:
未结题
起止时间:
2023-03-01 至 2028-03-01

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中文摘要
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英文摘要
Breast cancer is the most frequently diagnosed cancer and second leading cause of cancer death among Canadian women. Estrogen signaling contributes to mammary tumorigenesis and is mediated by estrogen receptor alpha (ER), a major therapeutic target in ~2/
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Mechanisms of action of antiestrogens in breast cancer: roles of Ubi-like modifications in transcriptional inactivation of Estrogen Receptor alpha.
  • 批准号:
    472352
  • 项目类别:
    Operating Grants
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Mader Sylvie N
  • 依托单位:
Mechanisms of action of antiestrogens: towards improved treatment of relapse in ER+ breast cancer
  • 批准号:
    372071
  • 项目类别:
    Operating Grants
  • 资助金额:
    $54.34万
  • 财政年份:
    2017
  • 负责人:
    Mader Sylvie N
  • 依托单位:
Mechanisms controlling estrogen receptor alpha expression and activity in breast tumorigenesis
  • 批准号:
    358549
  • 项目类别:
    Operating Grants
  • 资助金额:
    $66.32万
  • 财政年份:
    2016
  • 负责人:
    Mader Sylvie N
  • 依托单位:
Mechanisms of action of full antiestrogens
  • 批准号:
    268027
  • 项目类别:
    Operating Grants
  • 资助金额:
    $50.72万
  • 财政年份:
    2012
  • 负责人:
    Mader Sylvie N
  • 依托单位:
海外基金