A Catalytic Synthesis of Cross-Conjugated Trienes: A Scaffold for Rapidly Increasing Molecular Complexity

本研究的重点是利用异位Pauson-Khand反应通过正构醛烯反应制备交叉共轭三烯的合成方法的发展。反应的范围将被确定，所产生的信息将用于指导合成具有有趣生物学特性的复杂分子。这项研究还将有助于更好地理解过渡金属催化的碳-碳键形成反应。通过这个奖项，有机和大分子化学项目支持了匹兹堡大学化学系Kay M. Brummond博士的研究。Brummond教授将专注于利用过渡金属开发构建分子复合物和生物相关化合物的新策略。以烯官能团为重点的碳-碳键形成反应将被强调。该方法对制药和农业行业具有潜在影响，该项目是培养研究生的绝佳工具。

The focus of this research is the development of synthetic methodology using the allenic Pauson-Khand reaction to prepare cross-conjugated trienes via a formal Alder-ene reaction. The scope of the reaction will be determined and the resulting information will be used to guide the synthesis of complex molecules having interesting biological properties. The research will also lead to a better understanding of transition metal catalyzed carbon-carbon bond forming reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Kay M. Brummond of the Department of Chemistry at the University of Pittsburgh. Professor Brummond will focus her efforts on the use of transition metals for the development of new strategies for the construction of molecularly complex and biologically relevant compounds. Carbon-carbon bond forming reactions with an emphasis on the allene functional group will be emphasized. The methodology has potential impact for the pharmaceutical and agricultural industries and the project is an excellent vehicle for the training of graduate students.