A Catalytic Synthesis of Cross-Conjugated Trienes: A Scaffold for Rapidly Increasing Molecular Complexity

本研究的重点是利用二烯的Pauson-Khandd反应通过正式的Alder-ene反应制备交叉共轭三烯的合成方法。反应的范围将被确定，由此产生的信息将被用于指导具有有趣生物学特性的复杂分子的合成。这项研究还将使人们更好地了解过渡金属催化的碳-碳键形成反应。凭借这一奖项，有机和高分子化学计划支持匹兹堡大学化学系的凯·M·布鲁蒙德博士的研究。Brummond教授将把她的工作重点放在利用过渡金属开发构建分子络合物和生物相关化合物的新策略上。将重点介绍以烯丙基为重点的碳-碳键形成反应。该方法对制药和农业行业有潜在的影响，该项目是培养研究生的极好工具。

The focus of this research is the development of synthetic methodology using the allenic Pauson-Khand reaction to prepare cross-conjugated trienes via a formal Alder-ene reaction. The scope of the reaction will be determined and the resulting information will be used to guide the synthesis of complex molecules having interesting biological properties. The research will also lead to a better understanding of transition metal catalyzed carbon-carbon bond forming reactions.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Kay M. Brummond of the Department of Chemistry at the University of Pittsburgh. Professor Brummond will focus her efforts on the use of transition metals for the development of new strategies for the construction of molecularly complex and biologically relevant compounds. Carbon-carbon bond forming reactions with an emphasis on the allene functional group will be emphasized. The methodology has potential impact for the pharmaceutical and agricultural industries and the project is an excellent vehicle for the training of graduate students.