Mechanisms and Application of Dehydro-Diels-Alder Cycloadditions

脱氢-Diels-Alder环加成反应机理及应用

• 批准号: 1956024
• 负责人: Kay Brummond
• 金额: $ 49万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1956024&HistoricalAwards=false
• 关键词: Mechanisms; Application; Dehydro; Diels; Alder

With this award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Kay Brummond at the Department of Chemistry, University of Pittsburgh. Professor Brummond and her group are studying dearomative dehydro-Diels-Alder (DDDA) reactions using a combined experimental and computational approach in collaboration with the group of Professor Peng Liu. Elucidating details of the bond reorganization that occurs in these transformations is important so that chemists are better able to rationally expand the generality of the reaction. This chemistry is also of great value from an applications standpoint as predictable DDDA chemistry allows for control of the structural characteristics of the product that underlie the desirable physical properties of these systems. The findings from these investigations are being applied to the design of new strategies for preparing novel compounds of societal importance, in particular, high-performing organic photovoltaic materials. The collaborative approach is affording the next-generation of scientific problem-solvers and communicators equipped with a breadth of experience and chemical expertise to ask the right questions and provide innovative solutions. Professor Brummond is also combining training and mentoring of next generation of chemists with a top-down approach to implement diversity, equity, and inclusivity strategies at the departmental and college level, to provide a far-reaching and powerful platform for broadening participation of underrepresented groups in science, technology, engineering, and mathematics (STEM). The dehydro-Diels–Alder reaction is a powerful method for preparing highly unsaturated six-membered rings; however, when these reactions involve the dearomatization of a heteroarene, harsh conditions and the formation of multiple products compromise their usefulness. Professor Brummond and her research group are working to improve the synthetic utility of dearomative dehydro-Diels–Alder (DDDA) reactions by determining factors that control reactivity and product selectivity for heteroarenes. Both experimental and computational mechanistic studies are being performed in tandem to systematically establish electronic and steric trends, as well as increase computational reliability. Computational studies are being done in collaboration with the research group of Professor Peng Liu, also at the University of Pittsburgh. Expansion of the synthetic utility of the DDDA reaction is also being achieved through the synthesis of novel ladder-type heteroarene compounds. Convergent methods to design and synthesize high performing organic photovoltaic materials from these ladder-type conjugated structures are being developed and will provide valuable alternatives to cross-coupling approaches. The target selection process is being guided by computational property predictions performed by an expert in theoretical modeling and simulation of organo-electronic materials. Professor Brummond is committed to broadening participation in STEM by increasing diversity, equity, and inclusivity (DEI) in chemistry specifically and in the natural sciences using methodology that incorporates both a bottom-up approach, maintaining an active research group focused on advising and mentoring the next generation of organic chemists, and a top-down approach, leveraging her position as an academic leader and associate dean for the Kenneth P. Dietrich School of Arts and Sciences, to champion evidence-based strategies to change culture, policies, and practices to close DEI gaps in the sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

有了这个奖项，NSF化学部的化学合成计划正在支持匹兹堡大学化学系Kay Brummond教授的研究。Brummond教授和她的团队正在与刘鹏教授的团队合作，采用实验和计算相结合的方法研究脱芳香脱氢-狄尔斯-桤木（DDDA）反应。阐明在这些转化中发生的键重组的细节是重要的，以便化学家能够更好地合理地扩展反应的一般性。从应用的角度来看，这种化学性质也具有很大的价值，因为可预测的DDDA化学性质允许控制产品的结构特征，这些结构特征是这些系统的理想物理性质的基础。这些研究的结果正被应用于设计新的策略，以制备具有社会重要性的新型化合物，特别是高性能的有机光伏材料。这种协作方法为下一代科学问题解决者和沟通者提供了丰富的经验和化学专业知识，可以提出正确的问题并提供创新的解决方案。Brummond教授还将下一代化学家的培训和指导与自上而下的方法相结合，以在部门和学院层面实施多样性，公平性和包容性战略，为扩大科学，技术，工程和数学（STEM）中代表性不足的群体的参与提供一个深远而强大的平台。 脱氢-Diels-桤木反应是制备高度不饱和六元环的有效方法;然而，当这些反应涉及杂芳烃的脱芳构化时，苛刻的条件和多种产物的形成损害了它们的有用性。Brummond教授和她的研究小组正在努力通过确定控制杂芳烃反应性和产物选择性的因素来提高脱芳脱氢-Diels-桤木（DDDA）反应的合成效用。实验和计算机制的研究正在进行串联，以系统地建立电子和空间的趋势，以及增加计算的可靠性。计算研究正在与匹兹堡大学的刘鹏教授的研究小组合作进行。DDDA反应的合成效用的扩展也通过合成新的梯形杂芳烃化合物来实现。从这些梯形共轭结构设计和合成高性能有机光伏材料的收敛方法正在开发中，并将提供交叉耦合方法的有价值的替代方案。目标选择过程由有机电子材料理论建模和模拟专家进行的计算属性预测指导。Brummond教授致力于通过增加多样性，公平性和包容性（DEI）来扩大对STEM的参与，特别是在化学和自然科学中，使用的方法包括自下而上的方法，保持一个活跃的研究小组，专注于为下一代有机化学家提供咨询和指导，以及自上而下的方法。利用她作为肯尼斯·P·迪特里希艺术与科学学院学术领袖和副院长的地位，倡导以证据为基础的战略，以改变文化，政策，该奖项反映了NSF的法定使命，并被认为值得通过使用基金会的知识价值和更广泛的影响审查标准进行评估来支持。