GOALI: Characterization of Dense Colloidal Suspensions With Frequency-Domain Photon Migration (FDPM)

摘要提案编号：CTS-0213280主要研究者：Sevick-Muraca，伊娃隶属于：德克萨斯州工程Exp Sta职务：GOALI -使用FDPM表征稠密胶体悬浮液在该项目中，PI建议（i）开发和测试新的逆算法，用于根据实验多波长FDPM数据评估单分散、二元和多分散悬浮液中的粒度和粒度分布，（ii）评估FDPM测量的散射性质的变化所产生的耗尽力，静电相互作用，和胶体功能化与配体受体系统的生物意义;和（iii）评估这些变化的背景下的第一原理模型的部分结构因子。 GOALI项目的最终目标是开发一种低成本、简单的诊断工具，用于表征稠密悬浮液中胶体颗粒之间的相互作用。 该系统扩展到在线表征的中间体和最终的胶体产品计划用于化学，制药和生物技术行业。

ABSTRACTProposal Number: CTS-0213280Principal Investigator: Sevick-Muraca, Eva MAffiliation: Texas Engineering Exp StaTitle: GOALI - Characterization of Dense Colloidal Suspensions with FDPMIn this project, the PI proposes to (i) develop and test new inverse algorithms for assessing particle size and size distribution in monodisperse, binary, and polydisperse suspensions from experimental multi-wavelength FDPM data, (ii) assess changes in FDPM measured scattering properties arising from depletion force, electrostatic interactions, and colloids functionalized with ligand receptor systems of biological significance; and (iii) evaluate those changes in the context of first principles models of partial structure factor. The final objective of the GOALI project is to develop a low cost, simple diagnostics tool in characterize the interaction between colloidal particles in dense suspensions. Extension of the system to on-line characterization of intermediate and final colloidal products is planned for chemical, pharmaceutical, and biotechnology industries.