GOALI: Characterization of Dense Colloidal Suspensions With Frequency-Domain Photon Migration (FDPM)

建议编号：CTS-0213280主要研究员：Sevick-Muraca，Eva M从属关系：德克萨斯工程经验STAT标题：GOALI-用FDPM表征致密胶体悬浮液在本项目中，PI建议(I)开发和测试新的逆算法，用于从实验多波长FDPM数据评估单分散、双分散和多分散悬浮液中的颗粒尺寸和粒度分布，(Ii)评估FDPM测量的散射特性的变化，这些变化由具有生物学意义的配基受体系统的耗尽力、静电相互作用和胶体引起；以及(Iii)在部分结构因子第一原理模型的背景下评估这些变化。GOALI项目的最终目标是开发一种低成本、简单的诊断工具来表征稠密悬浮液中胶体颗粒之间的相互作用。计划将该系统扩展到中间和最终胶体产品的在线表征，用于化学、制药和生物技术行业。

ABSTRACTProposal Number: CTS-0213280Principal Investigator: Sevick-Muraca, Eva MAffiliation: Texas Engineering Exp StaTitle: GOALI - Characterization of Dense Colloidal Suspensions with FDPMIn this project, the PI proposes to (i) develop and test new inverse algorithms for assessing particle size and size distribution in monodisperse, binary, and polydisperse suspensions from experimental multi-wavelength FDPM data, (ii) assess changes in FDPM measured scattering properties arising from depletion force, electrostatic interactions, and colloids functionalized with ligand receptor systems of biological significance; and (iii) evaluate those changes in the context of first principles models of partial structure factor. The final objective of the GOALI project is to develop a low cost, simple diagnostics tool in characterize the interaction between colloidal particles in dense suspensions. Extension of the system to on-line characterization of intermediate and final colloidal products is planned for chemical, pharmaceutical, and biotechnology industries.