RUI: Synthesis and Cyclization Chemistry of Functionalized Fluorinated Allenes

PI建议使用官能化的氟化烯来开发新的氟化环构造方法。他们将首先制备一些单氟烯和二氟烯。将研究这些化合物的金属化、烷基化和取代反应，然后研究它们在环化反应中的应用，以制备含氟杂环和碳环。通过这一奖项，有机和高分子化学项目支持了马萨诸塞大学达特茅斯分校的杰拉尔德·B·哈蒙德博士的研究。哈蒙德博士和他的学生同事将研究一系列被称为氟化烯的有机氟分子的制备和反应化学反应。许多药物和农用化学品是含有有机氟的分子，该小组将为这些类型的分子开发新的合成灌浆。在这项工作过程中培训的学生将获得合成有机氟化学方面的经验，并获得制药和农化行业所需的技能。

The PI proposes to use functionalized, fluorinated allenes to develop new fluorinated ring construction methodologies. They will first prepare a number of mono and difluoroallenes. The metallation, alkylation and substitution reactions of these compounds will be investigated followed by a study of their use in cyclization reactions to prepare both fluorinated heterocycles and carbocycles. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Gerald B. Hammond of the University of Massachusetts at Dartmouth. Dr. Hammond and his student co-workers will study the preparation and reaction chemistry of a number of organofluorine molecules known as fluorinated allenes. Many pharmaceuticals and agrochemicals are organofluorine containing molecules and this group will be devloping new synthetic groutes to these types of molecules. Students trained during the course of this work will gain experience in synthetic organofluorine chemistry and be acquiring skills needed by the pharmaceutical and agrochemical industries.