RUI: Synthesis and Cyclization Chemistry of Functionalized Fluorinated Allenes

RUI：功能化氟化烯的合成和环化化学

• 批准号: 0213502
• 负责人: Gerald Hammond
• 金额: $ 23.4万
• 依托单位: University of Massachusetts, Dartmouth
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0213502&HistoricalAwards=false
• 关键词: RUI; Synthesis; Cyclization; Chemistry; Functionalized

The PI proposes to use functionalized, fluorinated allenes to develop new fluorinated ring construction methodologies. They will first prepare a number of mono and difluoroallenes. The metallation, alkylation and substitution reactions of these compounds will be investigated followed by a study of their use in cyclization reactions to prepare both fluorinated heterocycles and carbocycles. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Gerald B. Hammond of the University of Massachusetts at Dartmouth. Dr. Hammond and his student co-workers will study the preparation and reaction chemistry of a number of organofluorine molecules known as fluorinated allenes. Many pharmaceuticals and agrochemicals are organofluorine containing molecules and this group will be devloping new synthetic groutes to these types of molecules. Students trained during the course of this work will gain experience in synthetic organofluorine chemistry and be acquiring skills needed by the pharmaceutical and agrochemical industries.

PI建议使用功能化的氟化烯来开发新的氟化环构建方法。他们将首先制备一些单氟烯和二氟烯。将研究这些化合物的金属化、烷基化和取代反应，然后研究它们在环化反应中的应用，以制备氟化杂环和碳环。有了这个奖项，有机和大分子化学项目支持了马萨诸塞大学达特茅斯分校的Gerald B. Hammond博士的研究。哈蒙德博士和他的学生同事将研究一些被称为氟化烯的有机氟分子的制备和反应化学。许多药物和农用化学品都是含有机氟分子，该小组将开发新的合成基团来处理这些类型的分子。在这项工作过程中训练的学生将获得合成有机氟化学的经验，并获得制药和农用化学品工业所需的技能。